John O Semmes

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The innate ability of the human cell to silence endogenous retroviruses through RNA sequences encoding micro-RNAs, suggests that the cellular RNAi machinery is a major mean by which the host mounts a response against contemporary retroviruses, such as HIV-1 and HTLV-1. Several recent publications have identified cellular miR-NAs that target and hybridize to(More)
BACKGROUND AND PURPOSE Susceptibility to multiple sclerosis (MS) is determined by environmental and genetic factors, but the cause remains unknown. Changes to the proteome prior to first symptom onset may reflect the underlying pathophysiology of the disease. METHODS This preliminary study utilized pre-symptomatic and post-symptomatic serum from a sample(More)
HTLV-1 Tax protein displays pleotropic activities that regulate many aspects of virus biology, host-pathogen interaction and disease development. Tax performs these various functions via protein-protein interactions and sub cellular compartmentalization appears to regulate which activities are engaged. We previously identified a novel nuclear body, Tax(More)
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