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  • Andrew C.R. Epstein, Jonathan M. Gleadle, Luke A. McNeill, Kirsty S. Hewitson, John O'Rourke, David R. Mole +14 others
  • 2001
HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. Recent studies have defined posttranslational modification by prolyl hydroxylation as a key regulatory event that targets HIF-alpha subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Here, we define a conserved HIF-VHL-prolyl(More)
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