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The study aimed to clarify the effects of severe traumatic brain injury (TBI) on visual memory. Three groups of participants (14 late-recovery and 14 early-recovery TBI individuals and 18 controls) were administered the following: The Shum Visual Learning Test (SVLT), a test that measures the ability to remember visual patterns, an electronic maze test, a(More)
Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-based immunotherapy against Aβ to trigger its clearance or mitigate its neurotoxicity has so far been unsuccessful. Here we report the generation of aducanumab, a(More)
In the double-blind, placebo-controlled, Phase 3 DEFINE study in patients with relapsing–remitting multiple sclerosis, oral BG-12 (dimethyl fumarate) significantly reduced the proportion of patients relapsed (primary endpoint), the annualized relapse rate (ARR), and confirmed disability progression (secondary endpoints) at two years compared with placebo.(More)
In the phase 3, randomized, placebo-controlled and active reference (glatiramer acetate) comparator CONFIRM study in patients with relapsing-remitting multiple sclerosis, oral BG-12 (dimethyl fumarate) reduced the annualized relapse rate (ARR; primary endpoint), as well as the proportion of patients relapsed, magnetic resonance imaging lesion activity, and(More)
The study sought to determine whether, as implied by a trait interpretation of individual differences in non-specific electrodermal responding, the frequency of NSRs is a consistent characteristic of subjects across conditions. 40 male subjects completed two 1-hour sessions spaced at an interval of 2 weeks. In each session, three 12-min conditions were(More)
The Depression Anxiety Stress scale (DASS) is a widely used instrument for assessing mental health status, but the construct validity of the Chinese version of the test has not been demonstrated. The current study recruited three independent samples of Chinese participants to examine its reliability, factor structure, and utility in differentiating groups(More)
The effects of incentive and preparation on performance and classification accuracy of standard and malingering-specific tests were investigated in a simulation study using a 2 (no incentive vs. a $20 incentive) x 2 (immediate vs. delayed preparation) factorial design. Eighty undergraduate students and 15 individuals with traumatic brain injury were(More)