John Napier

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Insulin-like growth factor-I (IGF-I) has been shown to stimulate myoblast proliferation for a limited time after which serum is required to reactivate IGF-I-stimulated myoblast proliferation. The aim of these studies was to determine whether IGF-I can stimulate myoblast proliferation and/or inhibit apoptosis alone or whether co-factors are necessary. This(More)
Reversed-phase chromatography (RPC) was used to resolve two variants of recombinant amino terminal methionyl residue (N-Met) insulin-like growth factor-I (IGF-I) with the same amino acid constitution but different disulphide linkages. Following radioiodination, equilibration with plasma and size exclusion chromatography at neutral pH the major form on RPC(More)
There is a disconnection between commercial architecture and environmental thinking, where green features can be included as part of a strategy for gaining approvals and marketing projects, but those features are not reviewed after completion and occupation of the building and knowledge is not shared. High levels of air conditioning are still considered(More)
Manchester Civil Justice Centre is a striking contemporary 14 storey court building which has won awards for many different aspects of its design, construction and sustainability. From November 2002 to July 2005, the author was a key member of Denton Corker Marshall's London project team having responsibility for key areas of design development, integration(More)
Reliability is of prime importance in computer-based safety critical systems where failure can lead to fatal consequences. Fault tolerant techniques in software have a vital role to play, because veriication and validation techniques cannot guarantee that software is error free. Fault tolerance further improves the reliability of the system by ensuring it(More)
Current design and assessment methods cannot ensure that software is error free and consequently fault tolerant techniques play an important role in safety critical systems to ensure reliable software behaviour. Unfortunately general guidelines for the implementation of software diagnostics are lacking. The aim of this work is to build on the previous(More)
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