John Muller

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The anterior cruciate ligament (ACL) fails to heal after suture repair. One hypothesis for this failure is the premature loss of the fibrin clot, or provisional scaffolding, between the two ligament ends in the joint environment. To test this hypothesis, a substitute provisional scaffold of collagen-platelet rich plasma (PRP) hydrogel was used to fill the(More)
1 Abstract Software components are deployed in tightly coupled environments within the context of a component model. Techniques such as Prediction-Enabled Component Technology (PECT) [4] combine component technologies with analysis models to address the issue of consumer trust in the quality of assemblies. Service-oriented thinking and challenges(More)
With business drivers such as innovation and the constant influence of changing requirements, organizations seek ways to increase time-to-market capability, enhance overall productivity and maintain or improve product quality. At the same time these organizations strive to leverage legacy investments. Assets unbundled from these legacy systems, acquired(More)
Recent evidence has suggested that the N-methyl-D-aspartate receptor antagonist ketamine shows significant therapeutic effects in major depression and bipolar disorder. This effect is especially important in treatment-resistant depression and depression with suicidal ideation. In this review we explain the mechanism of action, drug efficacy, and the side(More)
Biological fluid collection to identify and analyze different disease markers is a routine and normal procedure in health care settings. Body fluids are as varied as urine, blood, mucus, cerebrospinal fluid (CSF), tears, semen, etc. The volumes of the collected fluids range from micro liters (e.g., tears, CSF) to tens and hundreds of milliliters (blood,(More)
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