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With the prevalent use of DXA-measured BMD to assess pathologic hip fractures and its recently reported lack of reliability to predict fracture or account for efficacy of anti-resorptive therapy, it is reasonable to assess whether variations in the primary and secondary tensile and compressive trabecular microstructure can account for variations in proximal(More)
The anterior cruciate ligament (ACL) fails to heal after suture repair. One hypothesis for this failure is the premature loss of the fibrin clot, or provisional scaffolding, between the two ligament ends in the joint environment. To test this hypothesis, a substitute provisional scaffold of collagen-platelet rich plasma (PRP) hydrogel was used to fill the(More)
The anterior cruciate ligament (ACL) of the knee fails to heal after primary repair. Here we hypothesize that a beneficial biologic repair response can be induced by placing a collagen-platelet rich plasma (collagen-PRP) material into a central ACL defect. A collagen-PRP scaffold was used to treat a central ACL defect in vivo. In the first experiment, the(More)
UNLABELLED We used QCT scans obtained in 687 men and women, 21-97 years of age, to estimate the factor of risk for vertebral fracture, Phi(vert), defined as the ratio of spinal loading to vertebral strength. With age, vertebral strength declined and Phi(vert) increased significantly more in women than men. Age- and sex-specific differences in Phi(vert)(More)
Murine bone specimens are used extensively in skeletal research to assess the effects of environmental, physiologic and pathologic factors on their mechanical properties. Given the destructive nature of mechanical testing, it is normally performed as a terminal procedure, where specimens must be preserved without affecting their mechanical properties. To(More)
Areal BMD (aBMD) derived from DXA is currently the gold standard for diagnosis of osteoporosis. A biomechanical approach to fracture risk assessment comparing the ratio of applied load to bone strength, termed the factor of risk (Phi), may be useful to better identify patients at risk for fracture. We obtained 73 human cadaveric femurs (48 women and 25 men,(More)
1 Abstract Software components are deployed in tightly coupled environments within the context of a component model. Techniques such as Prediction-Enabled Component Technology (PECT) [4] combine component technologies with analysis models to address the issue of consumer trust in the quality of assemblies. Service-oriented thinking and challenges(More)
With business drivers such as innovation and the constant influence of changing requirements, organizations seek ways to increase time-to-market capability, enhance overall productivity and maintain or improve product quality. At the same time these organizations strive to leverage legacy investments. Assets unbundled from these legacy systems, acquired(More)