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OBJECTIVE Overweight and obesity are often assumed to be risk factors for postprocedural mortality in patients with coronary artery disease (CAD). However, recent studies have described an "obesity paradox" -- a neutral or beneficial association between obesity and mortality postcoronary revascularization. We reviewed the effect of overweight and obesity(More)
BACKGROUND Carbonic anhydrase enzymes (CA) catalyze the reversible hydration of carbon dioxide to bicarbonate in mammalian cells. Trans-membrane transport of CA-produced bicarbonate contributes significantly to cellular pH regulation. A body of evidence implicates pH-regulatory processes in the hypertrophic growth pathway characteristic of hearts as they(More)
BACKGROUND The effect of extended donor ischemic times on mortality following heart transplantation is a matter of considerable debate. PATIENTS AND METHODS A retrospective study of the 261 consecutive heart transplantations performed at the centre (University of Alberta, Edmonton, Alberta) between July 1985 and June 1999 was conducted. Patients were(More)
BACKGROUND Rejection remains a significant cause of morbidity and mortality after lung transplantation. The purpose of this study was to test the efficacy and safety of daclizumab (DZM) vs anti-thymocyte globulin (ATG) as a component of induction therapy. METHODS Fifty adults undergoing lung transplantation were randomized to receive either ATG or DZM(More)
A 54-year-old man with no cardiac history presented with exertional angina. Cardiac catheterization revealed an anomalous right coronary artery originating from the left main coronary artery with external compression during its course between the aorta and the pulmonary artery. He was successfully managed with surgical reimplantation of the right coronary(More)
BACKGROUND The authors sought to examine in-hospital and one-year outcomes of off-pump coronary artery bypass grafting (CABG) and to determine the subgroups of patients most likely to benefit from the off-pump procedure in a regular surgical practice. METHODS From March 2001 to December 2002, 1657 consecutive patients were treated with off-pump CABG and(More)
BACKGROUND The bicaval technique of orthotopic heart transplantation, in contrast to the standard biatrial technique, may better preserve right atrial anatomy and, thus, may be associated with less sinus node dysfunction and less atrioventricular valve dysfunction. OBJECTIVES To compare the requirement for permanent pacemaker insertion and the incidence(More)
The case of a patient undergoing successful surgical resection of a huge lipoma of the right atrium is presented. The diagnosis was established preoperatively by magnetic resonance imaging. The tumor was involved intimately with the right coronary artery, and careful identification and dissection were required to preserve the vessel. The tumor was removed(More)