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OBJECTIVE Overweight and obesity are often assumed to be risk factors for postprocedural mortality in patients with coronary artery disease (CAD). However, recent studies have described an "obesity paradox" -- a neutral or beneficial association between obesity and mortality postcoronary revascularization. We reviewed the effect of overweight and obesity(More)
BACKGROUND Carbonic anhydrase enzymes (CA) catalyze the reversible hydration of carbon dioxide to bicarbonate in mammalian cells. Trans-membrane transport of CA-produced bicarbonate contributes significantly to cellular pH regulation. A body of evidence implicates pH-regulatory processes in the hypertrophic growth pathway characteristic of hearts as they(More)
BACKGROUND Among patients undergoing mitral-valve surgery, 30 to 50% present with atrial fibrillation, which is associated with reduced survival and increased risk of stroke. Surgical ablation of atrial fibrillation has been widely adopted, but evidence regarding its safety and effectiveness is limited. METHODS We randomly assigned 260 patients with(More)
BACKGROUND The effect of extended donor ischemic times on mortality following heart transplantation is a matter of considerable debate. PATIENTS AND METHODS A retrospective study of the 261 consecutive heart transplantations performed at the centre (University of Alberta, Edmonton, Alberta) between July 1985 and June 1999 was conducted. Patients were(More)
BACKGROUND The bicaval technique of orthotopic heart transplantation, in contrast to the standard biatrial technique, may better preserve right atrial anatomy and, thus, may be associated with less sinus node dysfunction and less atrioventricular valve dysfunction. OBJECTIVES To compare the requirement for permanent pacemaker insertion and the incidence(More)
BACKGROUND The authors sought to examine in-hospital and one-year outcomes of off-pump coronary artery bypass grafting (CABG) and to determine the subgroups of patients most likely to benefit from the off-pump procedure in a regular surgical practice. METHODS From March 2001 to December 2002, 1657 consecutive patients were treated with off-pump CABG and(More)
BACKGROUND Rejection remains a significant cause of morbidity and mortality after lung transplantation. The purpose of this study was to test the efficacy and safety of daclizumab (DZM) vs anti-thymocyte globulin (ATG) as a component of induction therapy. METHODS Fifty adults undergoing lung transplantation were randomized to receive either ATG or DZM(More)
BACKGROUND AND AIM Accepting donors of advanced age may increase the number of hearts available for transplantation. Objectives were to review the outcomes of using cardiac donors 50 years of age and older and to identify predictors of outcome at a single institution. METHODS A retrospective analysis of all adult cardiac transplants (n = 338) performed at(More)
The antemortem diagnosis of cardiac metastases in osteogenic sarcoma has been documented in only 25 cases over the past 50 years, whereas a prevalence as high as 20% is seen at autopsy, suggesting that cardiac involvement is a late stage complication. As the survival times for primary osteosarcoma continue to improve, previously rare, late stage(More)