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Menarcheal age was estimated for 287 (188 Black; 99 White) urban South African girls born in Soweto-Johannesburg in 1990. The median menarcheal age for Blacks was 12.4 years (95% confidence interval (CI) 12.2, 12.6) and 12.5 years (95% CI 11.7, 13.3) for Whites. Data from six studies of menarcheal age, including the current study, were analyzed to examine(More)
OBJECTIVE To determine whether African urban children who were stunted at 2 years of age demonstrated an altered body composition by the end of childhood, before entering puberty, at 9 years of age. RESEARCH METHODS AND PROCEDURES This was a mixed-longitudinal study of 330 prepubertal African children (182 boys) from Soweto-Johannesburg, South Africa.(More)
BACKGROUND Low- to middle-income countries are undergoing a health transition with non-communicable diseases contributing substantially to disease burden, despite persistence of undernutrition and infectious diseases. This study aimed to investigate the prevalence and patterns of stunting and overweight/obesity, and hence risk for metabolic disease, in a(More)
OBJECTIVE To determine which aspects of socio-economic status (SES) measured at birth and at ages 9 or 10 years, are associated with body composition at ages 9 or 10 years. DESIGN Mixed longitudinal cohort. SETTING Johannesburg-Soweto South Africa. PARTICIPANTS A sub-sample of the Birth to Twenty (Bt20) cohort (n = 281) with data on birth weight,(More)
We examined undecalcified transiliac bone samples from 346 normal black and white South African adults (age range 21-83 years) by routine histomorphometry. The results were analysed for race-, age- and sex-dependent characteristics of trabecular microstructure (bone volume, trabecular thickness, trabecular number, trabecular separation) and static bone(More)
AIM To examine ethnic and sex differences in the pattern of skeletal maturity from adolescence to adulthood using a novel longitudinal analysis technique (SuperImposition by Translation And Rotation (SITAR)). SETTING Johannesburg, South Africa. PARTICIPANTS 607 boys and girls of black as well as white ethnicity from the Birth to Twenty bone health(More)
OBJECTIVE To investigate predictors of adolescent obesity in rural South Africa. DESIGN Cross-sectional study. Height, weight and waist circumference were measured using standard procedures. Overweight and obesity in adolescents aged 10-17 years were assessed using the International Obesity Taskforce cut-offs, while the WHO adult cut-offs were used for(More)
OBJECTIVE To test the hypothesis that individuals on antiretroviral therapy (ART) for 3 months with a greater body mass index (BMI) as a result of supplementary feeding with ready-to-use fortified spread would maintain a higher BMI 9 months after the feeding ended. METHODS Two cohorts of wasted adults with AIDS, after 12 months of ART and 3 months of(More)
BACKGROUND HIV-infected children are at high risk of developing tuberculosis after infection by Mycobacterium tuberculosis. Emphasis is placed on tuberculin skin testing (TST) for diagnosing tuberculosis in children; however, its value in HIV-infected children is controversial. OBJECTIVES To determine whether concurrent antigen testing and/or CD4+(More)