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TeraGrid is a national-scale computational science facility supported through a partnership among thirteen institutions, with funding from the US National Science Foundation [1]. Initially created through a Major Research Equipment Facilities Construction (MREFC [2]) award in 2001, the TeraGrid facility began providing production computing, storage,(More)
The catastrophic destruction of the World Trade Center (WTC) on 11 September 2001 caused the release of high levels of airborne pollutants into the local environment. To assess the toxicity of fine particulate matter [particulate matter with a mass median aerodynamic diameter < 2.5 microm (PM2.5)], which may adversely affect the health of workers and(More)
This article describes the Open Science Grid, a large distributed computational infrastructure in the United States which supports many different high-throughput scientific applications, and partners (federates) with other infrastructures nationally and internationally to form multi-domain integrated distributed systems for science. The Open Science Grid(More)
An increasing number of algorithms for biochemical network inference from experimental data require discrete data as input. For example, dynamic Bayesian network methods and methods that use the framework of finite dynamical systems, such as Boolean networks, all take discrete input. Experimental data, however, are typically continuous and represented by(More)
Epidemiologic reports by C.A. Pope III et. al. demonstrated that in the Utah Valley, closure of an open-hearth steel mill over the winter of 1987 was associated with reductions in respiratory disease and related hospital admissions in valley residents. To better examine the relationship between plant-associated changes in ambient particulate matter (PM) and(More)
Several studies have reported health effects of concentrated ambient particles (CAP) in rodents and humans; however, toxicity end points in rodents have provided inconsistent results. In 2000 we conducted six 1-day exposure studies where spontaneously hypertensive (SH) rats were exposed to filtered air or CAPs (< or = 2.5 microm, 1,138-1,765 microg/m3) for(More)
BACKGROUND Epidemiologic studies have reported an association between proximity to highway traffic and increased cardiopulmonary illnesses. OBJECTIVES We investigated the effect of size-fractionated particulate matter (PM), obtained at different distances from a highway, on acute cardiopulmonary toxicity in mice. METHODS We collected PM for 2 weeks in(More)
The NSF TeraGrid project has designed and constructed a federated integrated information service (IIS) to serve its capability publishing and discovery needs. This service has also proven helpful in automating TeraGrid's operational activities. We describe the requirements that motivated this work; IIS's system architecture, information architecture, and(More)
Risk assessments often must consider exposures that vary over time or for which the exposure duration of concern differs from the available data, and a variety of extrapolation procedures have been devised accordingly. The present experiments explore the relationship(s) between exposure concentration (C) and time (t) to investigate procedures for assessing(More)