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Compromised heat shock protein 90 (Hsp90) function reveals cryptic phenotypes in flies and plants. These observations were interpreted to suggest that this molecular stress-response chaperone has a capacity to buffer underlying genetic variation. Conversely, the protective role of Hsp90 could account for the variable penetrance or severity of some heritable(More)
  • Michal Grzmil, Danny Whiting, John Maule, Corina Anastasaki, James F. Amatruda, Robert N. Kelsh +2 others
  • 2007
BACKGROUND Int-6 (integration site 6) was identified as an oncogene in a screen of tumorigenic mouse mammary tumor virus (MMTV) insertions. INT6 expression is altered in human cancers, but the precise role of disrupted INT6 in tumorigenesis remains unclear, and an animal model to study Int-6 physiological function has been lacking. PRINCIPAL FINDINGS(More)
This study investigated the perception of colorful ensembles and the effect of categories and perceptual similarity on their representation. We briefly presented ensembles of two hues and tested hue recognition with a range of seen and unseen hues. The average hue was familiar, even though it never appeared in the ensembles. Increasing the perceptual(More)
It is claimed that the extraction of average features from rapidly presented ensembles is holistic, with attention distributed across the whole set. We investigated whether observers' extraction of mean hue is holistic or could reflect subsampling. Analysis of selections for the mean hue revealed a distribution that peaked at the expected mean hue. However,(More)
The ability to extract the mean of features from a rapidly viewed, heterogeneous array of objects has been demonstrated for a number of different visual properties. Few studies have previously investigated the rapid averaging of color; those that did had insufficient stimulus control or inappropriate methods. This study reports three experiments that(More)
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