John Matson

Yimin Hua2
Frank Rigo2
Gene Hung2
C Frank Bennett2
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Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by mutations in the SMN1 gene that result in a deficiency of SMN protein. One approach to treat SMA is to use antisense oligonucleotides (ASOs) to redirect the splicing of a paralogous gene, SMN2, to boost production of functional SMN. Injection of a(More)
Spinal muscular atrophy (SMA) is a debilitating neuromuscular disease caused by the loss of survival of motor neuron (SMN) protein. Previously, we demonstrated that ISIS 396443, an antisense oligonucleotide (ASO) targeted to the SMN2 pre-mRNA, is a potent inducer of SMN2 exon 7 inclusion and SMN protein expression, and improves function and survival of mild(More)
  • Dipti U Desai, Dipti Uday Desai, Harriger Alka, Prof, Magana Alejandra, Eric Prof +8 others
  • 2013
This is to certify that the thesis/dissertation prepared By Entitled For the degree of Is approved by the final examining committee: Chair To the best of my knowledge and as understood by the student in the Research Integrity and Copyright Disclaimer (Graduate School Form 20), this thesis/dissertation adheres to the provisions of Purdue University's "(More)
  • Peigen Cao, Bonnie Sheriff, William Dichtel, Clara, Ji-Hyun Cho, Yi Luo +76 others
  • 2011
Acknowledgements There are many people to whom I would like to express my gratitude. First and foremost I would like to thank my advisor, Professor Jim Heath. I'm so grateful for his constant support and guidance during my graduate studies. His intensive enthusiasm to the pursuit of science has always been inspiring me and motivating me to think creatively(More)
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