John M. X. Hughes

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AIMS/HYPOTHESIS Referred to as CCN, the family of growth factors consisting of cystein-rich protein 61 (CYR61, also known as CCN1), connective tissue growth factor (CTGF, also known as CCN2), nephroblastoma overexpressed gene (NOV, also known as CCN3) and WNT1-inducible signalling pathway proteins 1, 2 and 3 (WISP1, -2 and -3; also known as CCN4, -5 and -6)(More)
Protein synthesis utilizes a large proportion of the available free energy in the eukaryotic cell and must be precisely controlled, yet up to now there has been no systematic rate control analysis of the in vivo process. We now present a novel study of rate control by eukaryotic translation initiation factors (eIFs) using yeast strains in which chromosomal(More)
EXPERIMENTAL Chemistry. NMR spectra were recorded on a 400 MHz spectrometer and referenced to the solvent. Reactions were monitored by TLC using standard silica gel plates. All chemicals were obtained from commercial sources, and the solvents were of analytical grade. Substrates 1-9a and 12a and products 1-2b and 4-8b, along with methyl(More)
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