John M Dose

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Regional levels of lactate and free fatty acids (FFA) were measured after lateral fluid percussion (FP) brain injury in rats. At 5 min after injury, tissue concentrations of lactate were elevated in the cortices and hippocampi of both ipsilateral and contralateral hemispheres. Whereas lactate levels had returned to normal by about 20 min after injury in the(More)
Regional levels of phosphatidylinositol 4,5-bisphosphate (PIP2), diacylglycerol (DG) and free fatty acids (FFA), involved in the signal transduction pathway of the excitatory neurotransmitter system, were measured after lateral fluid percussion (FP) brain injury in rats. At 5 min postinjury, tissue PIP2 concentrations were significantly reduced in the(More)
This study examined the effects of the administration of D-amphetamine on the regional accumulation of lactate and free fatty acids (FFAs) after lateral fluid percussion (FP) brain injury in the rat. Rats were subjected to either FP brain injury of moderate severity (1.9 to 2.0 atm) or sham operation. At 5 min after injury, rats were treated with either(More)
The influence of d-amphetamine on timing in pigeons was examined with a production procedure. Birds were trained with a fixed time schedule in which food reinforcement was contingent on the first response made after a duration signal had appeared for 30 s. Probe tests involved trials in which the duration signal was extended to 90 s and reinforcement was(More)
Regional concentrations of leukotriene C4 and extravasation of Evans blue were measured after lateral fluid-percussion brain injury in rats. Tissue levels of LTC4 were elevated in the injured cortex at 10 min, 30 min, and 1 h after injury; these levels returned to normal by 2 h after injury. Increases in the levels of LTC4 were also observed in the(More)
The separate and combined effects of dopamine D1 and D2 agonists on key-peck responding of young chicks for heat reinforcement were determined. In the first experiment, 1- and 4-day-old chicks (n = 96) were injected SC with either distilled water or 5 mg/kg reserpine 18 h before testing. Twenty minutes before a 24-trial autoshaping session, chicks were(More)
This study examined the effects of (D)-amphetamine, methoxamine (an al-adrenergic receptor agonist), and prazosin (an al-adrenergic receptor antagonist) on the behavioral outcome of lateral fluid percussion brain injury. Rats trained to perform a beam walking task were subjected to brain injury of moderate severity (2.1-2.2 atm). At 10 min after injury,(More)
This study examined the delayed effects of the administration of d-amphetamine, methoxamine (an alpha1-adrenergic receptor agonist), and prazosin (an alpha1-adrenergic receptor antagonist) on the behavioral outcome of lateral fluid-percussion (FP) brain injury. Rats trained to perform a beam-walking task were subjected to brain injury of moderate severity(More)
The physiological and behavioral effects of embryonic exposure to ethanol and cocaine, given during active neurogenesis (embryonic days E3 and E4), were studied in 1- and 2-day-old chicks. Broiler chicks (n = 131) from five embryonic treatment conditions were tested: incubative controls (n = 28), vehicle (saline plus 50 micrograms/ml bacitracin; n = 27), 10(More)
Three experiments examined the dose-dependent biphasic effect of morphine on odor conditioning in neonatal rats. In Experiment 1, a single pairing of an odor and a low dose of morphine (0.5 mg/kg) in 5-day-old rats produced an odor preference, relative to an unpaired control group. In Experiment 2, pairing an odor with a high dose of morphine (2.0 mg/kg)(More)