John Loch

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Recent research on hidden-state reinforcement learning (RL) problems has concentrated on overcoming partial observability by using memory to estimate state. However, such methods are computationally extremely expensive and thus have very limited applicability. This emphasis on state estimation has come about because it has been widely observed that the(More)
The 5-HT3 receptor antagonist tropisetron (ICS 205-930) was found to be a potent and selective partial agonist at alpha7 nicotinic receptors. Two other 5-HT3 receptor antagonists, ondansetron and LY-278,584, were found to lack high affinity at the alpha7 nicotinic receptor. Quinuclidine analogues (1 and 2) of tropisetron were also found to be potent and(More)
Neuronal nicotinic acetylcholine receptors are members of the ligand-gated ion channel receptor superfamily and may play important roles in modulating neurotransmission, cognition, sensory gating, and anxiety. Because of its distribution and abundance in the CNS, the alpha 7 nicotinic receptor is a strong candidate to be involved in some of these functions.(More)
This paper describes a series of experiments that were performed on the Rocky III robot. 1 Rocky III is a small autonomous rover capable of navigating through rough outdoor terrain to a predesignated area, searching that area for soft soil, acquiring a soil sample, and depositing the sample in a container at its home base. The robot is programmed according(More)
The suboptimal efficacy of the currently available 23-valent pneumococcal vaccine in the growing population of adults >65 years old may be related to the limited immunogenicity of the vaccine polysaccharides in this group. In this study, the majority of elderly outpatients with stable chronic illnesses generated a vigorous IgG response to seven vaccine(More)
Agents acting in the real world are confronted with the problem of making good decisions with limited knowledge of the environment. Partially observable Markov decision processes (POMDPs) model decision problems in which an agent tries to maximize its reward in the face of limited sensor feedback. Recent work has shown empirically that a reinforcement(More)
A reflexive hierarchical control architecture is developed which generates a trajectory that attains a goal position while avoiding obstacles and underwater terrain for an autonomous underwater vehicle (AUV) being developed by the M. The reflexive hierarchical control architecture consists of multiple modules that independently generate control commands for(More)
This paper describes a series of experiments that were performed on the Rocky III rob0t.l Rocky III is a small autonomous rover capable of navigating through rough outdoor terrain to a predesignated area, searching that area for soft soil, acquiring a soil sample, and depositing the sample in a container at its home base. The robot is programmed according(More)
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