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Journals and Conferences
A central feature of the inflammatory pathology in Alzheimer's disease is activated microglia clustered around aggregated amyloid beta (Abeta) peptide-containing plaques. In vitro-cultured microglia can be activated to an inflammatory state by aggregated Abeta with the induction of a range of different neurotoxic factors and provide a model system for… (More)
PURPOSE The combination of cisplatin plus gemcitabine is active in metastatic breast cancer. Carboplatin plus gemcitabine, widely used in ovarian and non-small-cell lung cancers, has also been used in breast cancer. This trial examined the efficacy and toxicity of split-dose carboplatin plus gemcitabine in advanced breast cancer. PATIENTS AND METHODS… (More)
The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monkeys.
A central feature of the inflammatory pathology in Alzheimer's disease is activated mi-croglia clustered around aggregated amyloid ␤ (A␤) peptide-containing plaques. In vitro-cultured microglia can be activated to an inflamma-tory state by aggregated A␤ with the induction of a range of different neurotoxic factors and provide a model system for studying… (More)
UNLABELLED A positive blood culture is a critical result that requires prompt identification of the causative agent. This article describes a simple method to identify microorganisms from positive blood culture broth within the time taken to perform a Gram stain (<20 min). The method is based on intrinsic fluorescence spectroscopy (IFS) of whole cells and… (More)
Author Correction for Hyman et al., Evaluation of a fully automated research prototype for the immediate identification of microorganisms from positive blood cultures under clinical conditions. mBio 7(3):e00705-16.
Multimedia is a buzzword that sometimes signifies more fluff than substance, especially when it refers to a glitzy presentation that slowly feeds to a single user from a CD-ROM. multimedia also refers to high speed electronic delivery of large data sets to as many as 17 simultaneous art history students under their self-paced control, so that they can… (More)
UNLABELLED A clinical laboratory evaluation of an intrinsic fluorescence spectroscopy (IFS)-based identification system paired to a BacT/Alert Virtuo microbial detection system (bioMérieux, Inc., Durham, NC) was performed to assess the potential for fully automated identification of positive blood cultures. The prototype IFS system incorporates a novel… (More)