John Li Tat Chen

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BACKGROUND The morbidity and mortality associated with malaria are heightened because of the spread of drug-resistant parasites and the lack of an effective vaccine. Plasmodium liver stages are the targets of new chemotherapeutics and vaccines, but there are limited tools available to study this stage in vivo. METHODS To overcome this obstacle, we(More)
STUDY DESIGN A prospective study over a 3.5-year period involving transcranial magnetic stimulation and magnetic resonance imaging. OBJECTIVES To assess the correlation of transcranial magnetic stimulation and magnetic resonance imaging in cervical spondylotic myelopathy qualitatively and statistically. SUMMARY OF BACKGROUND DATA Cervical spondylotic(More)
To describe our centre’s results, experience and technical points learnt with the SKy Bone Expander System for osteoporotic vertebral compression fractures (VCFs). Forty consecutive patients with painful single level T12 or L1 osteoporotic VCF who had failed conservative management for more than 3 months had 40 single level SKy Bone Expander kyphoplasties(More)
STUDY DESIGN This was a prospective, nonrandomized study. OBJECTIVES To assess the accuracy of O-arm navigation-based pedicle screw insertion in lumbar degenerative spondylolisthesis and to compare it with free-hand pedicle screw insertion technique in matched population. SUMMARY OF BACKGROUND DATA O-arm navigation is latest in navigation technology(More)
BACKGROUND CONTEXT Multilevel cervical myelopathy can be treated with anterior cervical discectomy and fusion (ACDF) or corpectomy via the anterior approach and laminoplasty via the posterior approach. Till date, there is no proven superior approach. PURPOSE To elucidate any potential advantage of one approach over the other with regard to clinical(More)
OBJECTIVE Cervical spondylosis (CS) often results in various degrees of cord compression, which can be evaluated functionally with transcranial magnetic stimulation (TMS). We investigate the use of TMS as a screening tool for myelopathy in CS. METHODS We prospectively studied 231 patients classified into Groups 1 to 4 based on MRI grading of severity of(More)
STUDY DESIGN prospective study. OBJECTIVE present results of Prestige LP artificial cervical disc replacement (ADR). SUMMARY OF BACKGROUND DATA motion preservation with ADR can potentially reduce adjacent segment degeneration. METHODS.: Forty patients with 59 Prestige LP ADR were analyzed. Cervical range of motion, Neck Disability Index, Visual(More)
BACKGROUND AND PURPOSE Outcome measurement has been shown to improve performance in several fields of healthcare. This understanding has driven a growing interest in value-based healthcare, where value is defined as outcomes achieved per money spent. While low back pain (LBP) constitutes an enormous burden of disease, no universal set of metrics has yet(More)
pose potential health risks, particularly to young children. While California has reported more cases of baylisascariasis than any other state, few published studies have reported on the distribution and prevalence of this helminth in the region. In 2001, we conducted a study to determine the presence of B. procyonis in the Santa Barbara area by examining(More)
BACKGROUND Cervical spondylotic myelopathy (CSM) results in sensorimotor limb deficits, bladder, and bowel dysfunction, but mechanisms underlying motor plasticity changes before and after surgery are unclear. METHODS We studied 24 patients who underwent decompression surgery and 15 healthy controls. Patients with mixed upper and lower limb dysfunction(More)