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Many complex domains and even larger problems in simple domains remain challenging in spite of the recent progress in planning. Besides developing and improving planning technologies, re-engineering a domain by utilising acquired knowledge opens up a potential avenue for further research. Moreover, macro-actions, when added to the domain as additional(More)
Puberty onset is initiated by activation of neurons that secrete gonadotropin-releasing hormone (GnRH). The timing and progression of puberty may depend upon temporal coordination of two opposing central mechanisms--a restraint of GnRH secretion before puberty onset, followed by enhanced stimulation of GnRH release to complete reproductive maturation during(More)
Classic experiments have shown that ovulation and estrous cyclicity are under circadian control and that surgical ablation of the suprachiasmatic nuclei (SCN) results in estrous acyclicity in rats. Here, we characterized reproductive function in the circadian Clock mutant mouse and found that the circadian Clock mutation both disrupts estrous cyclicity and(More)
The efficient scheduling of independent computational jobs in a heterogeneous computing (HC) environment is an important problem in domains such as grid computing. Finding optimal schedules for such an environment is (in general) an NP-hard problem, and so heuristic approaches must be used. In this paper we describe an ant colony optimisation (ACO)(More)
The Bin Packing Problem and the Cutting Stock Problem are two related classes of NP-hard combi-natorial optimisation problems. Exact solution methods can only be used for very small instances, so for real-world problems we have to rely on heuristic methods. In recent years, researchers have started to apply evolutionary approaches to these problems,(More)
The efficient scheduling of independent computational jobs in a heterogeneous computing (HC) environment is an important problem in domains such as grid computing. Finding optimal schedules for such an environment is (in general) an NP-hard problem, and so heuristic approaches must be used. Work with other NP-hard problems has shown that solutions found by(More)
Peripheral administration of N-methyl-D,L-aspartate (NMA), an analogue of the excitatory amino acid aspartate, elicits LH and prolactin (PRL) release in rats, most likely by increasing endogenous releasing-hormone secretion. These experiments were carried out to assess the degree to which NMA stimulates FSH and to analyze the relationship between endocrine(More)
It is well known that estrogen (E2) stimulates expression of progesterone receptors (PRs), thereby inducing responsiveness of several tissues to the actions of progesterone (P). Recent studies have also suggested, however, that biological actions previously ascribed to E2 alone may also be mediated by activation of E2-induced PRs, even independently of(More)
Progesterone's (P4) negative feedback actions in the female reproductive axis are exerted in part by suppression of hypothalamic GnRH release. Here we show that P4 can inhibit GnRH release by a mechanism independent of a nuclear P4 receptor (PR(A/B)). Injections of P4, but not vehicle, allopregnanolone, or dexamethasone, acutely suppressed LH levels in both(More)
W e are writing as scientists and editors of leading peer-reviewed journals that have published important contributions in the study of endocrine disrupting chemicals (EDCs). By signing this editorial, we affirm that regulatory decisions on EDCs should be made based on the best available science and expertise that involves, among others, reproductive(More)