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OBJECTIVE The objective of this study was to evaluate the safety and tolerance of increasing single and repeated (n = 2) doses of intramuscular naked plasmid DNA encoding for fibroblast growth factor (FGF) type 1 (NV1FGF) administered to patients with unreconstructible end-stage peripheral arterial occlusive disease (PAD). The secondary objectives were to(More)
The effect of cardiac contraction on coronary arterial flow has been described in terms of an intramyocardiaJ pump, which displaces blood backward and forward during systole and diastole, respectively. Normally, the mean forward flow exceeds, and consequently conceals, this backflow. The main left coronary artery of six anesthetized open-chest dogs was(More)
A wide variety of neuroendocrine tumours express somatostatin receptors, and can be visualized by radiolabelled somatostatin analogue scintigraphy. To investigate the value of [111In]-octreotide scintigraphy (Octreoscan), 48 patients (37 with proven carcinoid, pancreatic endocrine and medullary carcinoma of thyroid tumours, 11 with neuroendocrine syndromes(More)
EXPLOITING RELATIVE DURATIONS IN QUALITATIVE SIMULATION We show that qualitative simulation algorithms can make better use of their input to deduce significant amounts of information about the relative lengths of the time intervals in their output behavior predictions. Simple techniques employing concepts like symmetry, periodicity, and comparison of the(More)
Between January 1983 and March 1986, 75 consecutive patients underwent cervical exploration for primary hyperparathyroidism. Each patient had a thallium-technetium subtraction isotope scan of the neck performed preoperatively. Of 71 patients with technically satisfactory scans, 68 came to 'first-time' neck exploration while three underwent reoperation for(More)
We present a novel approach of saliency based image categorization using topic model. In each image, salient foreground objects are discriminated from background scene by saliency detection. Then topic model is used to jointly discover topics of foreground and background. Our approach can categorize images in a completely unsupervised manner and achieve(More)
Normally systolic coronary blood flow is almost entirely forward. As perfusion pressure was lowered through the autoregulatory range in open-chest dogs, net systolic back flow appeared at ∼70 mm Hg. Imposing a series resistance (Rs), which impedes both forward and back flow, abolished this reverse flow and resulted in net forward systolic flow. Thus we(More)