John L Straughan

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Certain drugs are well known to cause acute neurological crises in patients with hereditary coproporphyria, variegate porphyria and acute intermittent porphyria. Guidelines for drug therapy have been provided in this article, particular attention being paid to the manner in which the porphyrogenicity or safety of a drug has been assessed and providing full(More)
The methods used to identify and evaluate anti-inflammatory agents, and the effects of a triple drug regimen, consisting of oral prednisone and flufenamic acid and topical l-adrenaline in controlling bleb inflammation and fibrosis around drainage implants in patients with terminal glaucoma are described. The benefits of anti-inflammatory agents in other(More)
  • J L Straughan
  • South African medical journal = Suid-Afrikaanse…
  • 1979
While no major differences with regard to psychopharmacological actions are to be found among the benzodiazepines, certain pharmacokinetic differences are known. These differences allow the benzodiazepines to be classified as cumulative or non-cumulative; the differences between these two groups are further dissected and evaluated, in an attempt to(More)
Chlordiazepoxide and its 4 major metabolites were assayed after separation by thin-layer chromatography following extraction from biological fluids. The compounds become intensely fluorescent in the presence of red, fuming nitric acid. The resulting compounds are quantitated with a spectrodensitometer with a fluorescent attachment. The sensitivity varies(More)