John L. Baker

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The origins and functional significance of theta phase precession in the hippocampus remain obscure, in part, because of the difficulty of reproducing hippocampal place cell firing in experimental settings where the biophysical underpinnings can be examined in detail. The present study concerns a neurobiologically based computational model of the emergence(More)
Despite the central position of CA3 pyramidal cells in the hippocampal circuit, the experimental investigation of their synaptic properties has been limited. Recent slice experiments from adult rats characterized AMPA and NMDA receptor unitary synaptic responses in CA3b pyramidal cells. Here, excitatory synaptic activation is modeled to infer biophysical(More)
Three aspects of the definition of ALGOL 68 (van Wijngaarden et al., 1969) are modelled: (1) A style of grammar (vWg) with infinitely many productions and variables, corresponding to the ALGOL-68 "syntax" is defined; (2) The passage from "strict language" to "representation language" is formalized, essentially as an inverse gsm mapping; (3) Another style of(More)
Exposure to low-levels of lead (Pb) during early development has been implicated in behavioral abnormalities and cognitive deficits in children. The present study is focused on developmental changes in hippocampus and cerebellum of rats following perinatal exposure to Pb. Pregnant rats were exposed to 0.2% Pb-acetate from gestation day 6 (GD 6) through(More)
Although associational/commissural (A/C) and perforant path (PP) inputs to CA3b pyramidal cells play a central role in hippocampal mnemonic functions, the active and passive processes that shape A/C and PP AMPA and NMDA receptor-mediated unitary EPSP/EPSC (AMPA and NMDA uEPSP/uEPSC) have not been fully characterized yet. Here we find no differences in(More)
A significant benefit of computational models is that they mandate the explicit and quantitative account of all variables involved in the scientific problem being investigated. When a simulation is launched, the software program reads a series of parameter values that are assigned by the investigator. In compartmental models of neuronal electrophysiology,(More)
A computermodel of unitary responses from associational/ commissural and perforant path synapses in hippocampal CA3 pyramidal cells J Comput Neurosci (2011) 31:137–158 DOI 10.1007/s10827-010-0304-x Due to a publisher error, “A computer model of unitary responses from associational/commissural and perforant path synapses in hippocampal CA3 pyramidal cells”(More)
A cryogenically cooled hardware platform has been developed and commissioned on the Z Facility at Sandia National Laboratories in support of the Magnetized Liner Inertial Fusion (MagLIF) Program. MagLIF is a magneto-inertial fusion concept that employs a magnetically imploded metallic tube (liner) to compress and inertially confine premagnetized and(More)