John Krijnen

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The projections of the entorhinal cortex to CA1 in relation to the entorhinal-dentate projections were studied in the rat, using the anterograde transport of Phaseolus vulgaris leucoagglutinin. It was observed that the entorhinal cortex is heterogeneous with respect to the origin of these projections. Caudomedial portions of the entorhinal cortex mainly(More)
PURPOSE We evaluated the prognostic impact of neuroendocrine differentiation in prostate cancer with regard to the onset of endocrine therapy failure. MATERIALS AND METHODS A retrospective study was performed on 72 transurethral resection specimens from patients who subsequently underwent endocrine therapy for prostate cancer and were followed for 44 to(More)
The presence of androgen receptors (AR) in neuroendocrine cells was investigated in benign tissue of 10 prostatectomy specimens, in 12 prostatic adenocarcinomas with focal neuroendocrine differentiation and in 1 case of a pure neuroendocrine small cell carcinoma of the prostate. Neuroendocrine cells were defined by their reactivity with an antibody to(More)
A patient is described with a mortar shell shrapnel fragment in the anterior compartment of the right lower leg that had been in situ for 46 years without causing symptoms, when a large hematoma leading to a "chocolate cyst" developed around it. Initially, the patient was thought to have a malignant tumor. Roentgenograms and CT scans showed shrapnel(More)
Oligodendroglioma is a tumor of the central nervous system which rarely metastasizes. The diagnosis of oligodendroglioma is based on histomorphology with limited use of immunohistochemistry. However, recently a specific 1p/19q codeletion has been found which can be demonstrated by in situ hybridization. We report a case of a 58-years-old man with a(More)
We describe a case of intrauterine foetal death at 32 weeks gestation with signs of hydrops foetalis without erythroblastosis. The hydrops foetalis appeared to be caused by blood group incompatibility. Irregular antibodies of anti-K specificity were found in the serum of the mother, while the father was positive for the K-antigen. The antibody dependent(More)
D ij Background: An upper limb-activity monitor (ULAM) has been developed to determine activity limitations in complex regional pain syndrome type I (CRPSI). The ULAM is based on 24 h ambulatory monitoring of body segment accelerations and enables valid and objective quantification of mobility and upper limb activity in transversal studies. Aims: To explore(More)
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