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Future many-core processors will require high-performance yet energy-efficient on-chip networks to provide a communication substrate for the increasing number of cores. Recent advances in silicon nanophotonics create new opportunities for on-chip networks. To efficiently exploit the benefits of nanophotonics, we propose Firefly - a hybrid, hierarchical(More)
Evolving technology and increasing pin-bandwidth motivate the use of high-radix routers to reduce the diameter, latency, and cost of interconnection networks. High-radix networks, however, require longer cables than their low-radix counterparts. Because cables dominate network cost, the number of cables, and particularly the number of long, global cables(More)
Increasing integrated-circuit pin bandwidth has motivateda corresponding increase in the degree or radix of interconnection networksand their routers. This paper introduces the <i>flattened butterfly,</i> a cost-efficient topology for high-radix networks. On benign (load-balanced) traffic, the flattened butterfly approaches the cost/performance of a(More)
With the trend towards increasing number of cores in chip multiprocessors, the on-chip interconnect that connects the cores needs to scale efficiently. In this work, we propose the use of high-radix networks in on-chip interconnection net- works and describe how the flattened butterfly topology can be mapped to on-chip networks. By using high-radix routers(More)
On-chip network is becoming critical to the scalability of future many-core architectures. Recently, nanophotonics has been proposed for on-chip networks because of its low latency and high bandwidth. However, nanophotonics has relatively high static power consumption, which can lead to inefficient ar-chitectures. In this work, we propose FlexiShare – a(More)
MicroRNAs (miRNAs) constitute an extensive class of noncoding RNAs that are thought to regulate the expression of target genes via complementary base-pair interactions. To date, cloning has identified over 200 miRNAs from diverse eukaryotic organisms. Despite their success, such biochemical approaches are skewed toward identifying abundant miRNAs, unlike(More)
Three overlapping pathways mediate the transport of cytoplasmic material to the vacuole in Saccharomyces cerevisiae. The cytoplasm to vacuole targeting (Cvt) pathway transports the vacuolar hydrolase, aminopeptidase I (API), whereas pexophagy mediates the delivery of excess peroxisomes for degradation. Both the Cvt and pexophagy pathways are selective(More)
Evolving semiconductor and circuit technology has greatly increased the pin bandwidth available to a router chip. In the early 90s, routers were limited to 10Gb/s of pin bandwidth. Today 1Tb/s is feasible, and we expect 20Tb/s of I/O bandwidth by 2010. A high-radix router that provides many narrow ports is more effective in converting pin bandwidth to(More)
On-chip networks are critical to the scaling of future multi-core processors. The challenge for on-chip network is to reduce the cost including power consumption and area while providing high performance such as low latency and high bandwidth. Although much research in on-chip network have focused on improving the performance of on-chip networks, they have(More)
—Network-on-Chips (NoCs) are becoming integral parts of modern microprocessors as the number of cores and modules integrated on a single chip continues to increase. Research and development of future NoC technology relies on accurate modeling and simulations to evaluate the performance impact and analyze the cost of novel NoC architectures. In this work, we(More)