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A solution is provided to the problem of computing a convex set of conditional probability distributions that characterize the state of a nonlinear dynamic system as it evolves in time. The estimator uses the Galerkin approximation to solve Kolmogorov's equation for the diiusion of a continuous-time nonlinear system with discrete-time measurement updates.(More)
Major constituents of the amyloid plaques found in the brain of Alzheimer's patients are the 39-43 residue beta-amyloid (Abeta) peptides. Extensive in vitro as well as in vivo biochemical studies have shown that the 40- and 42-residue Abeta peptides play major roles in the neurodegenerative pathology of Alzheimer's disease. Although the two Abeta peptides(More)
Critical reagents are essential components of ligand binding assays (LBAs) and are utilized throughout the process of drug discovery, development, and post-marketing monitoring. Successful lifecycle management of LBA critical reagents minimizes assay performance problems caused by declining reagent activity and can mitigate the risk of delays during(More)
Metal ions have been shown to play a critical role in β-amyloid (Aβ) neurotoxicity, thus prompting an intense investigation into the formation of metal–Aβ complexes. Isothermal titration calorimetry (ITC) has been widely used to determine binding constants (K) for a variety of metal–protein interactions, including those in metal–Aβ complexes. In this study,(More)
With a simple tandem iterated sequence, the carboxyl terminal domain (CTD) of eukaryotic RNA polymerase II (RNAP II) serves as the central coordinator of mRNA synthesis by harmonizing a diversity of sequential interactions with transcription and processing factors. Despite intense research interest, many key questions regarding functional and evolutionary(More)
The number and size of tiger populations continue to decline owing to habitat loss, habitat fragmentation and poaching of tigers and their prey. As a result, tiger populations have become small and highly structured. Current populations have been isolated since the early 1970s or for approximately seven generations. The objective of this study is to explore(More)
SUMMARY Intelligent Transport System (ITS), aiming to provide innovative services related to traffic management, road safety and convenience , has drawn much attention in academic and industrial worlds in recent years. Japan has been considered as an advanced country in ITS development. This paper first gives an overview of the current ITS operated in Japan(More)
Dear Interested Readers, This report represents results from the laboratory portion of a project by the Division of Marine Fisheries and the Atlantic Offshore Lobstermen's Association to test the durability of different brands of sinking groundline. A line-testing machine was developed specifically for this project to simulate wear over time. While our(More)
Bovine brain, hypothalamus, pituitary, and retina contain potent anionic polypeptide mitogens for endothelial cells. Immunological assays using murine monoclonal antibodies against bovine endothelial cell growth factor (ECGF) and radioreceptor assays using [1251]ECGF were performed to determine the cross-reactivity of ECGF with bovine acidic pl(More)
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