John Kennelly

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The hippocampal dentate gyrus undergoes active neuronogenesis as well as growth and regression of neuronal elements and connections during the early postnatal period. In some brain regions, most notably in the visual system, both activity-dependent synaptic plasticity and NMDA receptor activation are candidate mechanisms by which neuronal architecture may(More)
The effects of rapid perforant path kindling on field potentials and paired pulse depression were studied in the dentate gyrus of rats at four developmental stages: 14-16 days, 20-22 days, 27-29 days and 40-60 days (adult). In rats 14-29 days kindling was associated with sustained potentiation of population spike amplitude and population EPSP slope; in(More)
The mammary gland undergoes dramatic functional and metabolic changes during the transition from late pregnancy to lactation. To better understand the molecular events underlying these changes, we analyzed expression profiles of approximately 23,000 gene transcripts in bovine mammary tissue about day 5 before parturition and day 10 after parturition. At the(More)
The bovine stearoyl-CoA desaturase (Scd) gene plays an important role in the bovine mammary gland where substrates such as stearic and vaccenic acids are converted to oleic acid and conjugated linoleic acid (CLA), respectively. Up to 90% of the CLA in bovine milk is formed due to the action of this enzyme in the mammary gland. The areas of the bovine(More)
BACKGROUND Blood pressure (BP) lowering medications have impressive efficacy in reducing cardiovascular and renal events; but low adherence threatens their effectiveness. Analysis of patterns in electronic prescribing from electronic medical records (EMRs) may have the potential to reveal cohorts of patients with significant adherence problems. METHODS We(More)
BACKGROUND Pay for performance incentives are becoming increasingly popular, but are typically based on only a single point-in-time measurement as an indicator of chronic condition management. AIMS To determine the association between three time-interval based indicators of suboptimal blood pressure (BP) control and two point-in-time indicators from the(More)
The effects of the primary biologically active conjugated linoleic acid (CLA) isomers (cis-9, trans-11 and trans-10, cis-12; 15-150microM) on growth and survival of the bovine mammary cell-line, Mac-T, were evaluated using cell enumeration and TUNEL assay. Previous studies have shown that high concentrations of CLA induced severe milk fat depression and(More)
PURPOSE Analysis of practice electronic medical records (EMRs) demonstrated widespread antihypertensive medication adherence problems in a Pacific-led general practice serving a predominantly Pacific (majority Samoan) caseload in suburban New Zealand. Adherence was quantified in terms of medication possession ratio (MPR, percent of days covered by(More)
Poor adherence to long-term prescription medication is a frequent problem that undermines pharmacological control of important risk factors such as hypertension. A medication possession ratio (MPR) can be calculated from Practice Management System (PMS) data to provide a convenient indicator of adherence. We investigate how well prior MPR predicts later(More)