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RATIONALE In idiopathic bronchiectasis, lung inflammation and chronic bacterial infection lead to progressive lung damage. A possible role for natural killer (NK) cells is suggested by the observation that familial bronchiectasis occurs in a rare group of individuals with impaired HLA class I expression and consequent NK cell dysfunction. OBJECTIVE(More)
Testing for mutations in the KRAS oncogene for patients with metastatic colorectal cancer (mCRC) is generally performed using DNA from formalin-fixed paraffin-embedded tumor tissue; however, access to specimens can be limited and analysis challenging. This study assessed the identification of KRAS mutations in circulating free DNA (cfDNA) using a(More)
BACKGROUND/OBJECTIVES Decreased plasma concentration of high-density lipoprotein cholesterol (HDL-C) is a risk factor linked to increased risk of cardiovascular disease (CVD). Decreased anti-atherogenic properties of HDL are also implicated in increased CVD risk. The cause is unknown but has been linked to impaired glucose tolerance. The aim of this study(More)
In the Depression decade, the research group headed by Wallace H. Carothers made two discoveries-neoprene and nylon-that have had an enormous impact on E. I. du Pont de Nemours and industrial research generally. At the same time, Carothers's many publications helped establish the foundations of polymer science. A theoretical organic chemist, he left Harvard(More)
Consider the following "snapshots" in the life of the Hercules Powder Co. of Wilmington, Delaware: In 1919 Hercules' total sales were $20.5 million. More than 99 percent of these revenues came from a single line of business: commercial explosives, including gunpowder, smokeless powder, blasting powder, and, especially, dynamite. These products were sold to(More)
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