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BACKGROUND Asthma guidelines indicate that the goal of treatment should be optimum asthma control. In a busy clinic practice with limited time and resources, there is need for a simple method for assessing asthma control with or without lung function testing. OBJECTIVES The objective of this article was to describe the development of the Asthma Control(More)
BACKGROUND The development of the Asthma Control Test (ACT), a short, simple, patient-based tool for identifying patients with poorly controlled asthma, was recently described in patients under the routine care of an asthma specialist. OBJECTIVES We sought to evaluate the reliability and validity of the ACT in a longitudinal study of asthmatic patients(More)
OBJECTIVE To summarize speech outcomes in children born with unilateral cleft lip and palate (UCLP) throughout the United Kingdom. DESIGN Prospective descriptive study on a cross-sectional sample of children. PATIENTS/PARTICIPANTS Data were collected for 238 5-year-olds (born between April 1, 1989, and March 31, 1991) and 218 12-year-olds (born between(More)
A clinical trial comparing the efficacy of a glass polyalkenoate cement (GPC) restoration with an amalgam cement restoration (ACR) in the management of caries in the deciduous molar dentition was undertaken. Two hundred and thirty-eight restorations, that is 119 pairs, were placed in 76 patients with an age range of 5 to 11 years. The durability of these(More)
Asthma is a chronic inflammatory disease of the airways which may involve an oxidant injury to the lung. Assessment of oxidant stress is difficult in vivo, but measurement of F2-isoprostanes (F2-IsoPs), free radical-catalysed products of arachidonic acid, appears to offer a reliable approach for quantitative measurement of oxidative stress status in vivo.(More)
OBJECTIVE To describe facial development and appearance, quality of bone grafts, oral health, and patient/parent satisfaction, with clinical outcome, for children in two age cohorts born with unilateral cleft lip and palate (UCLP) throughout the United Kingdom. DESIGN Cross-sectional outcome study. SETTING Fifty National Health Service cleft centers. (More)
Cigarette smoking is associated with increased mortality from cardiovascular disease that declines after cessation. This study extends the evidence regarding the effects of chronic smoking on platelets and the vessel wall in vivo. Excretion of a major urinary thromboxane metabolite, 2,3-dinor-thromboxane B2, is significantly (p less than .01) elevated in(More)
PURPOSE Small-bowel obstruction is a common complication after ileal pouch-anal anastomosis (IPAA). Acute angulation of the afferent limb at the pouch inlet is the cause of obstruction in a subset of patients requiring laparotomy. METHODS Patients were identified from the Lahey Clinic ileoanal pouch registry, a prospective computerized database of all(More)