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PURPOSE To compare survival and severe late radiation toxicity between patients who received continuous low-dose-rate (LDR) brachytherapy (BT) and pulsed-dose-rate (PDR) BT for cervical cancer. METHODS AND MATERIALS A retrospective review of cervical cancer patients who underwent primary radiotherapy with or without concurrent cisplatin was performed.(More)
PURPOSE To report results for 49 men with squamous cell carcinoma (SCC) of the penis treated with primary penile interstitial brachytherapy at one of two institutions: the Ottawa Regional Cancer Center, Ottawa, and the Princess Margaret Hospital, Toronto, Ontario, Canada. METHODS AND MATERIALS From September 1989 to September 2003, 49 men (mean age, 58(More)
We quantified the effect of seed orientation deviations on five prostate seed implant cases at our institution. While keeping their positions fixed, the iodine-125 seeds were assigned orientations sampled from a realistic probability distribution derived from the post-implant radiographs of ten patients. Dose distributions were calculated with both a model(More)
A major deficiency of current photon calculation methods that are based on the concept of primary and scatter separation is their inability to handle the condition of electronic disequilibrium. This deficiency is examined and it is shown that the limitation is not inherent in the algorithms themselves but is, at least in part, in the data which the(More)
A quality assurance system has been designed to verify the location and strength of seeds loaded in a brachytherapy eye plaque. This system consists of (1) a pinhole camera in conjunction with a Lumisys ACR-2000i computed radiography (CR) unit to image the location and measure the relative strength of the seeds with autoradiography, and (2) a source(More)
PURPOSE To determine the feasibility and benefits of optimized magnetic resonance imaging (MRI)-guided brachytherapy (BT) for cancer of the cervix. METHODS AND MATERIALS A total of 20 patients with International Federation of Gynecology and Obstetrics Stage IB-IV cervical cancer had an MRI-compatible intrauterine BT applicator inserted after external beam(More)
Forsythe has given a method for generating basis polynomials in a single variable that are orthogonal with respect to a given inner product. Weisfeld later demonstrated that Forsythe's approach could be extended to polynomials in an arbitrary number of variables. In this paper we sharpen Weisfeld's results and present a method for computing weighted,(More)
The dose distribution in small lung tumors (coin lesions) is affected by the combined effects of reduced attenuation of photons and extended range of electrons in lung. The increased range of electrons in low-density tissues can lead to loss of field flatness and increased penumbra width, especially at high energies. The EGSNRC Monte Carlo code, together(More)
PURPOSE Squamous carcinoma (SCC) of the penis affects about 1 in 100,000 men in western societies. Interstitial brachytherapy can be an effective penis-conserving modality for T1, T2, and selected T3 tumors. Unfortunately, few radiation oncology trainees have the opportunity to treat a case of penile cancer during their residency, and few centers have(More)
PURPOSE To quantify the dosimetric and radiobiological changes seen when using intensity-modulated radiation therapy (IMRT) or planning target volume (PTV) margin reduction with consistent planning parameters in a representative sample of localized prostate cancer patients. METHODS AND MATERIALS Twenty patients were randomly selected from a cohort that(More)