John J. Hanfelt

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Peripheral biomarkers to diagnose Alzheimer's disease (AD) have not been established. Given parallels between neuron and platelet biology, we hypothesized platelet membrane-associated protein changes may differentiate patients clinically defined with probable AD from noncognitive impaired controls. Purified platelets, confirmed by flow cytometry were(More)
BACKGROUND While the Glasgow Coma Scale (GCS) provides a tool for evaluating traumatic brain injury (TBI) patients, there is no widely used scale that provides guidance for surgical management. This study introduces a scoring system that physicians potentially could use to determine and communicate the need for surgical decompression in TBI patients. The(More)
OBJECTIVES/HYPOTHESIS The aim of this study was to define the coprevalence of tremor with spasmodic dysphonia (SD). STUDY DESIGN A single-institution, prospective, case-control study was performed from May 2010 to July 2010. METHODS Consecutive patients with SD (cases) and other voice disorders (controls) were enrolled prospectively. Each participant(More)
P revious reports have suggested that onset of diabetes occurs 4 –7 years before clinical diagnosis (1). However , it is not known whether delay in diagnosis reflects patient factors, such as lack of medical visits or glucose measurements , or provider factors, such as clinical inertia (2). We reviewed the charts of 50 patients selected for delayed(More)
This paper presents a robust method to conduct inference in finely stratified familial studies under proband-based sampling. We assume that the interest is in both the marginal effects of subject-specific covariates on a binary response and the familial aggregation of the response, as quantified by intrafamilial pairwise odds ratios. We adopt an estimating(More)
We consider methods for reducing the effects of fitting nuisance parameters on a general estimating function, when the estimating function depends on not only a vector of parameters of interest, θ, but also a vector of nuisance parameters , λ. We propose a class of modified profile estimating functions with plug-in bias reduced by two orders. A robust(More)
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