John J H Shin

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ABCG11/WBC11, an ATP binding cassette (ABC) transporter from Arabidopsis thaliana, is a key component of the export pathway for cuticular lipids. Arabidopsis wbc11 T-DNA insertional knock-out mutants exhibited lipidic inclusions inside epidermal cells similar to the previously characterized wax transporter mutant cer5, with a similar strong reduction in the(More)
Recognition of lipids by proteins is important for their targeting and activation in many signaling pathways, but the mechanisms that regulate such interactions are largely unknown. Here, we found that binding of proteins to the ubiquitous signaling lipid phosphatidic acid (PA) depended on intracellular pH and the protonation state of its phosphate(More)
Both osteoporosis and cardiovascular disease (CVD) are major public health problems leading to increased morbidity and mortality. Although traditionally viewed as separate disease entities that increase in prevalence with aging, accumulating evidence indicates that there are similar pathophysiological mechanisms underlying both diseases. In addition to(More)
OBJECT To date, angiography has been the primary modality for assessing graft patency following extracranial-intracranial bypass. The utility of a noninvasive and quantitative method of assessing bypass function postoperatively was evaluated using quantitative magnetic resonance (MR) angiography. METHODS One hundred one cases of bypass surgery performed(More)
ATP binding cassette (ABC) transporters play diverse roles, including lipid transport, in all kingdoms. ABCG subfamily transporters that are encoded as half-transporters require dimerization to form a functional ABC transporter. Different dimer combinations that may transport diverse substrates have been predicted from mutant phenotypes. In Arabidopsis(More)
ional athletes vanced degenaradigm shift tion experts. only an all-orso result from al detrimental nto the media veteran footer of the ball were heavier, after a 5-year tensive degenCTE were disted as cause of y” was docuA concussive episode refers to inertially induced duced traumatic alteration of function of the cere associated imaging abnormalities.(More)
Ganesh M. Shankar1,2 · Nina Lelic2 · Corey M. Gill3 · Aaron R. Thorner4,5 · Paul Van Hummelen4,5 · Jeffrey H. Wisoff6 · Jay S. Loeffler7 · Priscilla K. Brastianos1,3 · John H. Shin2 · Lawrence F. Borges2 · William E. Butler2 · David Zagzag6,10 · Rachel I. Brody10 · Ann‐Christine Duhaime2 · Michael D. Taylor11 · Cynthia E. Hawkins8 · David N. Louis9 · Daniel(More)
PURPOSE To evaluate patient selection criteria, methodology, safety and clinical outcomes of stereotactic body radiotherapy (SBRT) for treatment of vertebral metastases. MATERIALS AND METHODS Eight centers from the United States (n=5), Canada (n=2) and Germany (n=1) participated in the retrospective study and analyzed 301 patients with 387 vertebral(More)
Osteoporosis is a major public health problem with low bone mass affecting nearly half the women aged 50 years or older. Evidence from various studies has shown that higher body mass index (BMI) is a protective factor for bone mineral density (BMD). Most of the evidence, however, is from studies with Caucasian women and it is unclear to what extent(More)
Cardiovascular disease (CVD) is the major cause of morbidity and mortality in diabetes. To determine the proportion of patients who met the American Diabetes Association guidelines for control of CVD risk factors and to assess the achievement of these guidelines in women compared with men, we conducted a cross-sectional study of 3678 diabetic cohorts(More)