John J. Curtis

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BACKGROUND Osteopenia is a major complication of renal transplantation. Immunosuppressive regimens including cyclosporine, which permit the use of lower doses of glucocorticoids, may reduce glucocorticoid-induced osteopenia. METHODS We prospectively studied the magnitude, distribution, and mechanism of bone loss in 20 adults who received renal allografts(More)
PURPOSE Physicians increasingly prescribe cyclosporine as an immunosuppressive agent for both organ-transplant and non-organ-transplant recipients. Investigators have reported a high incidence of drug-induced hypertension even when clinical nephrotoxicity was not present. We wanted to determine the reason. PATIENTS AND METHODS A comparison was made of(More)
BACKGROUND Patients infected with hepatitis C virus (HCV) frequently develop renal failure after liver transplantation. OBJECTIVE To describe renal histologic characteristics and concomitant clinical features in HCV-infected patients with end-stage cirrhosis. DESIGN Case series. SETTING Single-center liver transplant program in the United States. (More)
  • J J Curtis
  • American journal of kidney diseases : the…
  • 1994
Patients often have hypertension after successful kidney transplantation. In the long term, this hypertension adds to patient mortality and morbidity. The widespread use of cyclosporine appears to have changed the nature of posttransplantation hypertension. In humans, cyclosporine-associated hypertension seems to involve sodium retention and stimulation of(More)
Previous studies of renal transplant recipients have suggested that weight gain after transplantation is relatively common, especially among certain populations. We conducted a retrospective review of 977 renal transplant recipients at the University of Alabama at Birmingham to identify patterns of weight change (as mean percentage of body weight at(More)
In fourteen renal transplant patients converted from cyclosporin to azathioprine for financial reasons renal blood flow was greater and renal vascular resistance lower after conversion. These changes occurred without any change in serum creatinine. This finding suggests that the renal allograft vasoconstriction induced by cyclosporin occurs before evidence(More)
Reflux nephropathy was diagnosed in 23 patients (14 per cent of all the patients who received transplants) between 1973 and 1977, and nephrectomy was performed in all. Histology and immunofluorescence revealed a glomerular sclerosis associated with the idiopathic nephrotic syndrome. No focal and segmental glomerular sclerosis was seen in kidneys removed(More)
Pericardial cystic lesions (PCLs) occur infrequently but are significant for their varying clinical presentation and pathological multitude. A review of the literature (including Medline and Current Contents database searches, and search of existing bibliographies) finds confusion in nomenclature and an absence of appropriate classification. A new(More)