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Bloom syndrome (BS) is an autosomal recessive disorder characterized by a high incidence of cancer and genomic instability. BLM, the protein defective in BS, is a RecQ-like helicase, presumed to function in DNA replication, recombination, or repair. BLM localizes to promyelocytic leukemia protein (PML) nuclear bodies and is expressed during late S and G2.(More)
AIMS We sought to investigate the impact of body mass index (BMI) on long-term all-cause mortality in patients following first-time elective percutaneous coronary intervention (PCI). METHODS AND RESULTS We used the Scottish Coronary Revascularisation Register to undertake a cohort study of all patients undergoing elective PCI in Scotland between April(More)
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract We give a compact expression for the number of factorizations of any(More)
We give a new expression for the number of factorizations of a full cycle into an ordered product of permutations of specified cycle types. This is done through purely algebraic means, extending work of Biane. We deduce from our result a formula of Poulalhon and Schaeffer that was previously derived through an intricate combinatorial argument. Our notation(More)
We count the number of lattice paths lying under a cyclically shifting piece-wise linear boundary of varying slope. Our main result extends well known enumerative formulae concerning lattice paths, and its derivation involves a classical reflection argument. A refinement allows for the counting of paths with a specified number of corners. We also apply the(More)
BACKGROUND The elderly account for an increasing proportion of the population and have a high prevalence of coronary heart disease. Percutaneous coronary intervention (PCI) is the most common method of revascularization in the elderly. We examined whether the risk of periprocedural complications after PCI was higher among elderly (age > or =75 years)(More)
Previous studies have implicated histone H5 dephosphorylation as a causal factor in genetic inactivation and chromatin condensation during erythroid senescence in adult chickens. We show that histone H5 phosphorylation declines in two stages as various cohorts of erythroid cells senesce in chick embryos. The first decline occurs between 5 and 6 days and(More)