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I compare the fees, expenses, and trading costs society pays to invest in the U.S. stock market with an estimate of what would be paid if everyone invested passively. Averaging over 1980–2006, I find investors spend 0.67% of the aggregate value of the market each year searching for superior returns. Society's capitalized cost of price discovery is at least(More)
Program slicing is an effective techniqe for narrowing the focus of attention to the relevant parts of a program during the debugging process. However, imprecision is a problem in static slices, since they are based on all possible executions that reach a given program point rather than the specific execution under which the program is being debugged. (More)
Mutations in ATP13A2 (PARK9), encoding a lysosomal P-type ATPase, are associated with both Kufor-Rakeb syndrome (KRS) and neuronal ceroid lipofuscinosis (NCL). KRS has recently been classified as a rare genetic form of Parkinson's disease (PD), whereas NCL is a lysosomal storage disorder. Although the transport activity of ATP13A2 has not been defined, in(More)
The effects of aging on the efficiency of RNA processing of AMPA glutamate receptor (GluR) subunits GluR1, GluR2, and GluR 3 was examined for RNA editing at the Q/R site of GluR2 and for alternative splicing of the flip or flop exons for GluR1-3. RNA isolated from six young (3 months old) and old (22-23 months old) animals was reverse-transcribed for PCR(More)
Ubiquitin-immunoreactive neuronal inclusions composed of TAR DNA binding protein of 43 kDa (TDP-43) are a major pathological feature of frontotemporal lobar degeneration (FTLD-TDP). In vivo studies with TDP-43 knockout mice have suggested that TDP-43 plays a critical, although undefined role in development. In the current report, we generated transgenic(More)
provides an international forum for discussion of a broad range of issues pertaining to death investigation. This year we have much to discuss and a wonderful host city to enjoy. Charlotte is a city where cosmopolitan character meets southern comforts. Our meeting will feature presentations and posters that cover a broad range of topics. There will be(More)
Frontotemporal lobar degeneration (FTLD) has been subdivided based on the main pathology found in the brains of affected individuals. When the primary pathology is aggregated, hyperphosphorylated tau, the pathological diagnosis is FTLD-tau. When the primary pathology is cytoplasmic and/or nuclear aggregates of phosphorylated TAR-DNA-binding protein(More)
Intel Technology Journal (February 2008) on Intel's Technologies and the Environment discusses a wide range of green technologies and efforts to conserve and sustain our natural environment through greener products, buildings, lifestyle, manufacturing and operations. Intel Corporation's four-decade history of technology innovations is a well-known fact.(More)
The Council of State and Territorial Epidemiologists (CSTE) in collaboration with the National Institute for Occupational Safety and Health (NIOSH) within the Centers for Disease Control and Prevention (CDC) are pleased to present the results of the pilot of CSTE's Occupational Health Indicators. CSTE would like to acknowledge the workgroup members for(More)