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Modern work is a highly social process, offering many cues for people to organize communication and access information. Shared physical workplaces provide natural support for tasks such as (a) <i>social reminding</i> about communication commitments and keeping track of collaborators and friends, and (b) <i>social data mining</i> of local(More)
BACKGROUND Everolimus, an oral inhibitor of the mammalian target of rapamycin (mTOR), has shown antitumour activity in patients with advanced pancreatic neuroendocrine tumours. We aimed to assess the combination of everolimus plus octreotide long-acting repeatable (LAR) in patients with low-grade or intermediate-grade neuroendocrine tumours (carcinoid). (More)
In a large online advertising system, adversaries may attempt to profit from the creation of low quality or harmful advertisements. In this paper, we present a large scale data mining effort that detects and blocks such adversarial advertisements for the benefit and safety of our users. Because both false positives and false negatives have high cost, our(More)
In a few short years, we have witnessed a massive uptake in the use of cell phones, personal digital assistants and hybrid devices that integrate phone, computer and Internet services. These devices communicate with one another and with traditional computers. Along with the Internet, they have transformed our computational environments into communication(More)
BACKGROUND Bevacizumab and erlotinib target different tumour growth pathways with little overlap in their toxic-effect profiles. On the basis of promising results from a phase 1/2 trial assessing safety and activity of erlotinib plus bevacizumab for recurrent or refractory non-small-cell lung cancer (NSCLC), we aimed to assess efficacy and safety of this(More)
Which organizing principle might be adapted for designing and developing advanced user interfaces affording information and communication services in a single integrated system? Our research on communication patterns in the workplace points to models of personal social networks. We have found that people invest considerable effort in maintaining links with(More)
A fundamental unit for user interfaces to existing communications applications is the message. However, empirical studies showed that people typically see their communication in terms of other people they interact with and personal social networks. Furthermore, important tasks such as keeping in touch, or tracking communication status, are not well(More)
This trial compared the efficacy and toxicity of standard first-line treatment with paclitaxel/carboplatin versus paclitaxel/carboplatin plus sorafenib in patients with advanced ovarian carcinoma. Patients with stage 3 or 4 epithelial ovarian cancer with residual measurable disease or elevated CA-125 levels after maximal surgical cytoreduction were(More)
Carcinoma of unknown primary site (CUP) is diagnosed in approximately 3 % of patients with advanced cancer, and most patients have traditionally been treated with empiric chemotherapy. As treatments improve and become more specific for individual solid tumor types, therapy with a single empiric combination chemotherapy regimen becomes increasingly(More)