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  • Ping Hu, Zhang Han, Anthony D. Couvillon, Randal J. Kaufman, John H. Exton
  • Medicine, Biology
  • Molecular and cellular biology
  • 2006 (First Publication: 15 April 2006)
  • NF-kappaB is critical for determining cellular sensitivity to apoptotic stimuli by regulating both mitochondrial and death receptor apoptotic pathways. The endoplasmic reticulum (ER) emerges as a newContinue Reading
  • John H. Exton
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 1999 (First Publication: 30 October 2002)
  • Phospholipase D (PLD) is a widely distributed enzyme that is under elaborate control by hormones, neurotransmitters, growth factors and cytokines in mammalian cells. Protein kinase C (PKC) plays aContinue Reading
  • Ping Hu, Zhang Han, Anthony D. Couvillon, John H. Exton
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2004 (First Publication: 19 November 2004)
  • Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of many diseases and in cancer therapy. Although the unfolded protein response is known to alleviate ER stress by reducingContinue Reading
  • John H. Exton
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1990 (First Publication: 5 January 1990)
  • Several mechanisms of agonist control of PC hydrolysis have been described: control by G proteins, protein kinase C, Ca2+, and tyrosine kinases. The relative importance of these mechanisms remains toContinue Reading