John H. Wallace

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OBJECTIVE To review the barriers to the uptake of research evidence from systematic reviews by decision makers. SEARCH STRATEGY We searched 19 databases covering the full range of publication years, utilised three search engines and also personally contacted investigators. Reference lists of primary studies and related reviews were also consulted. (More)
OBJECTIVE Little is known about the barriers, facilitators and interventions that impact on systematic review uptake. The objective of this study was to identify how uptake of systematic reviews can be improved. SELECTION CRITERIA Studies were included if they addressed interventions enhancing the uptake of systematic reviews. Reports in any language were(More)
Butyrivibrio fibrisolvens is the most active bacterial species in the biohydrogenation of polyunsaturated fatty acids (PUFA) in the rumen. It needs to remove the unsaturated bonds in order to detoxify the PUFA to enable the growth of the bacterium. Here, we investigated the response of cell membrane-associated proteins in B. fibrisolvens to growth in the(More)
CONTEXT The increased uptake of evidence from systematic reviews is advocated because of their potential to improve the quality of decision making for patient care. Systematic reviews can do this by decreasing inappropriate clinical variation and quickly expediting the application of current, effective advances to everyday practice. However, research(More)
The link between obesity and colorectal cancer risk in man is well established. This review investigates the role that the intestinal microbial population plays in this link and the impact of weight-loss diets on colorectal cancer risk. Changes in the composition of the intestinal bacterial community have been implicated in contributing to obesity. The(More)
Adult New Zealand white rabbits were experimentally infected with a parasitic African hemoflagellate, Trypanosoma congolense, and were subsequently tested for in vivo and in vitro aspects of cell-mediated immune function. Chronically infected rabbits were sensitized to mycobacterial protein and skin-tested with purified protein derivative; all infected(More)
An agglutinin has been isolated from leaves of the prickly lettuce plant (Lactuca scariole). The prickly lettuce agglutinin (PLA) agglutinates erythrocytes of the mouse and rat, and binds to, but does not agglutinate erythrocytes of other species. PLA can be precipitated from crude plant extracts by cold acetone and ammonium sulfate treatment, is sensitive(More)
A model of immune complex glomerulonephritis (ICGN) produced in mice by the daily injection of apoferritin was employed to study the effect of treatment with various doses of prostaglandin E2 (PGE2) on glomerular damage, immune complex deposition, proteinuria, and serum anti-apoferritin antibody. Administration of PGE2, 200 micrograms twice daily, resulted(More)