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PURPOSE We report a multicenter, double-blind, randomized trial of bilateral stimulation of the anterior nuclei of the thalamus for localization-related epilepsy. METHODS Participants were adults with medically refractory partial seizures, including secondarily generalized seizures. Half received stimulation and half no stimulation during a 3-month(More)
Immature hippocampal neurons (E-18) were maintained in defined medium for up to 3 weeks and their susceptibility to N-methyl-D-aspartic acid (NMDA)-induced cell death was studied at various days in vitro. Upon acute exposure to NMDA (5 min), hippocampal neurons in vitro (8-12 days after plating) showed cell body swelling and dendritic degeneration that(More)
OBJECTIVE The objective of the Brain Tumor Cooperative Group NIH Trial 87-01 trial was to investigate the effect of additional implanted radiation therapy in newly diagnosed patients with pathologically confirmed malignant gliomas. METHODS The study involved a randomized comparison of surgery, external beam radiotherapy, and carmustine (BCNU) versus(More)
BACKGROUND The subcutaneous placement of IPGs with electrodes to various intracranial and extracranial sites for the purpose of controlling conditions such as essential tremor, epilepsy, Parkinson's disease, and pain is increasing. Experience with similar placement of cardiac pacemakers and defibrillators had revealed the possibility of generator migration(More)
We describe a technical modification of the Leksell gamma stereotactic system that enables a direct transcerebellar biopsy of posterior fossa lesions. By using an additional pair of long (14 cm) posts placed in the posterior positions of the frame, the frame can be positioned low enough to allow for direct approaches to the posterior fossa. With the patient(More)
An attempted removal of a third ventricular cysticercosis cyst by an endoscopic approach was aborted before surgery when a preoperative scan demonstrated migration of the cyst into the fourth ventricle. In a second case, successful endoscopic removal of a cysticercosis cyst of the posterior third ventricle by a precoronal, transforaminal approach is(More)
A limited clinical pilot study involving an amalgam of specialized disciplines including neurology, neuropharmacology, neuropsychology, neurosurgery, neuroanesthesia, neuroradiology, surgical pathology, neuropathology, and urological surgery was organized to clarify issues related to patient selection, optimization of grafting materials, design of a safe,(More)
Hemlock woolly adelgid, Adelges tsugae Annand (Homoptera: Adelgidae), has two generations/year that feed and reproduce on hemlock, Tsugae spp. The spring generation, present from March to June, is called progrediens. The next generation, present from June until the following March, is called sistens (McClure 1987, Gray and Salom 1996). In June, after(More)
This paper deals with the aging and characterization of lithium-ion (Li-ion) batteries for life estimation evaluation. The most important aging characteristics of a real driving cycle for hybrid electric vehicle application, such as initial State of Charge (SoC) and Depth of Discharge (DoD), are used to synthesize an aging profile to be reproduced in(More)
Tumor cyst fluid from five patients with malignant glial neoplasms was assayed for mitogenic activity by measuring [3H]thymidine uptake by rat astrocyte cultures in serum-free defined media. Cyst fluid from all patients stimulated [3H]thymidine uptake three- to fourfold in astrocyte cultures in comparison with untreated controls. Mitogenic activity was(More)