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OBJECTIVE The objective of the Brain Tumor Cooperative Group NIH Trial 87-01 trial was to investigate the effect of additional implanted radiation therapy in newly diagnosed patients with pathologically confirmed malignant gliomas. METHODS The study involved a randomized comparison of surgery, external beam radiotherapy, and carmustine (BCNU) versus(More)
BACKGROUND The subcutaneous placement of IPGs with electrodes to various intracranial and extracranial sites for the purpose of controlling conditions such as essential tremor, epilepsy, Parkinson's disease, and pain is increasing. Experience with similar placement of cardiac pacemakers and defibrillators had revealed the possibility of generator migration(More)
An attempted removal of a third ventricular cysticercosis cyst by an endoscopic approach was aborted before surgery when a preoperative scan demonstrated migration of the cyst into the fourth ventricle. In a second case, successful endoscopic removal of a cysticercosis cyst of the posterior third ventricle by a precoronal, transforaminal approach is(More)
We describe a technical modification of the Leksell gamma stereotactic system that enables a direct transcerebellar biopsy of posterior fossa lesions. By using an additional pair of long (14 cm) posts placed in the posterior positions of the frame, the frame can be positioned low enough to allow for direct approaches to the posterior fossa. With the patient(More)
Immature hippocampal neurons (E-18) were maintained in defined medium for up to 3 weeks and their susceptibility to N-methyl-D-aspartic acid (NMDA)-induced cell death was studied at various days in vitro. Upon acute exposure to NMDA (5 min), hippocampal neurons in vitro (8-12 days after plating) showed cell body swelling and dendritic degeneration that(More)
A limited clinical pilot study involving an amalgam of specialized disciplines including neurology, neuropharmacology, neuropsychology, neurosurgery, neuroanesthesia, neuroradiology, surgical pathology, neuropathology, and urological surgery was organized to clarify issues related to patient selection, optimization of grafting materials, design of a safe,(More)
This paper describes the nature of the family involvement typically observed in anorexia nervosa and bulimia and the role of family therapy in a comprehensive treatment approach. Both the patterns of family interaction observed by clinicians and researchers and the varieties of family treatment used to address these disorders are described. The different(More)