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PURPOSE To test the hypothesis that a moderate electrical stimulation of the cervical sympathetic nerves in rabbits can increase intraocular pressure (IOP). METHODS Electrical stimulations of the cervical sympathetic nerves were performed in anesthetized and conscious rabbits. Intraocular pressure, pupil size, and concentrations of aqueous humor(More)
A unique circadian rhythm of intraocular pressure (IOP) occurs in laboratory rabbits housed in a light-dark environment. The IOP is low in the light and high in the dark. In 32 rabbits studied, the IOP was 18.7 +/- 0.3 mm Hg (mean +/- the standard error of the mean) at 2 hr before the onset of dark and 24.9 +/- 0.6 mm Hg at 2 hr into the dark. The changes(More)
Ocular sympathetic nerves were stimulated chronically in awake rabbits using electrodes unilaterally implanted on the cervical sympathetic trunk. IOP was measured by pneumatonometry and aqueous inflow was measured by fluorophotometry. In each animal, continuous trains of 1 msec pulses were delivered by means of a portable electrical stimulator. Experiments(More)
PURPOSE To study change patterns of 24 h intraocular pressure (IOP) in conscious and freely moving mice using telemetry. METHODS Adult C57BL/6J and CBA/CaJ mice were entrained to a standard 12 h light and 12 h dark cycle. A telemetric pressure transmitter was implanted subcutaneously on the upper back of each light-dark entrained mouse, and the pressure(More)
Intracerebroventricular (ICV) injection of carbachol into the third ventricle of conscious rabbits increased pupil size and intraocular pressure (IOP). A significant increase of pupil size by 0.6-1.3 mm for 60-90 min was observed with the dose of 1 microgram and an increase of IOP by 1.1-1.9 mmHg for 15-60 min was observed with doses over 10 ng. These(More)
PURPOSE The authors examined the circadian change of basal pupil size in light-dark entrained normal rabbits and in entrained rabbits with unilaterally decentralized ocular sympathetic nerves. The pattern of the circadian pupillary rhythm was compared with the circadian patterns of intraocular pressure (IOP) and body temperature in the same rabbits. (More)
Rabbits entrained in a daily light-dark environment show a circadian elevation of intraocular pressure (IOP) around the onset of dark. It was reported that concentration of cyclic AMP (cAMP) in aqueous humor increases significantly during this time period. Whether or not the increase of ocular cAMP-mediated activities is related to the circadian elevation(More)
  • Santa Barbara, Madhukar Reddy, Jim Umesh Allen, Prof Bob Mishra, York, Vita +85 others
  • 1997
ii Copyright by Madhukar Reddy 1997 iii Acknowledgments I am greatly indebted to Prof. Mark Rodwell for being my teacher, research advisor and mentor during the last five years. He has constantly amazed me with his ability to simplify complicated research problems. Despite my repeated failures, his enthusiasm and strong support motivated me to finally(More)
Hepatic ischemia/reperfusion (l/R) injury continues to be a critical problem. The role of nitric oxide in liver I/R injury is still controversial. This study examines the effect of endothelial nitric oxide synthase (eNOS) over-expression on hepatic function following I/R. Adenovirus expressing human eNOS (Ad-eNOS) was administered by tail vein injection(More)
PURPOSE The authors addressed three questions concerning the circadian rhythm of aqueous humor protein concentration in rabbits. First, is there an endogenous oscillator for this circadian rhythm? Second, does a circadian rhythm occur for individual aqueous humor protein components? Third, what is the role of ocular sympathetic nerves, which are more active(More)