John H. Chang

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PURPOSE To investigate the in vivo expression of toll-like receptor 4 (TLR4) and its associated lipopolysaccharide (LPS) receptor complex in the human eye. METHODS Normal human ocular tissues were evaluated for in vivo TLR4, MD-2, and CD14 mRNA and protein expression by RT-PCR and immunohistochemistry, respectively. The distribution patterns and(More)
PURPOSE To investigate the expression and polymorphisms of Toll-like receptor (TLR)-2 and -4 in the peripheral neutrophils and monocytes of patients with acute anterior uveitis (AAU). METHODS Nine patients with active AAU and nine age- and sex-matched healthy control subjects were studied. TLR2 and -4 protein expression on CD16(+) neutrophils and CD14(+)(More)
PURPOSE Ocular pigment epithelial cells are hypothesized to play a role in the pathogenesis of acute anterior uveitis (AAU), where LPS activation of Toll-like receptors (TLRs) may serve as a trigger. In this study, the expression of LPS receptors in iris pigment epithelium (IPE) was determined. METHODS RT-PCR, flow cytometry, Western blot, and(More)
A response time analysis for a general class of terminals-to-computer subsystem is presented in this paper. The model used is based on the most advanced data communications system in which terminals are connected to Terminal Control Units (T C U) that are in turn connected to local Front-End Processors (FEP). The line control procedures used to interface a(More)
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