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PURPOSE To establish whether it is possible to improve orbicularis oculi muscle function in the eyelids of patients with a chronic seventh cranial nerve palsy by using transcutaneous electrical stimulation to the point at which electrical stimulation induces a functional blink. METHODS Ten subjects (one woman, nine men) aged 36 to 76 with chronic,(More)
A line scan imaging system which provides a facility for comprehensive measurement and analysis of eyelid motion in human subjects is described. The device obtains parasagittal line images of the eye and eyelids by focusing an image of the eye onto a linear 256-element CCD array. Line images are acquired and digitized at a rate of 200 per second and stored(More)
Current practice for sample size computations in clinical trials is largely based on frequentist or classical methods. These methods have the drawback of requiring a point estimate of the variance of the treatment effect and are based on arbitrary settings of type I and II errors. They also do not directly address the question of achieving the best balance(More)
The genomic framework that enables corals to adjust to unfavourable conditions is crucial for coral reef survival in a rapidly changing climate. We have explored the striking intraspecific variability in the expression of coral pigments from the green fluorescent protein (GFP) family to elucidate the genomic basis for the plasticity of stress responses(More)
The behavioural Bayes approach to sample size determination for clinical trials assumes that the number of subsequent patients switching to a new drug from the current drug depends on the strength of the evidence for efficacy and safety that was observed in the clinical trials. The optimal sample size is the one which maximises the expected net benefit of(More)
  • Bo Chen, Vladimir Deineko, Richard Eglese, Adam Lechtford, Dolores Romero Morales, Chris Potts +6 others
  • 2012
With great pleasure I welcome you to Oxford and CO 2012, on behalf of the Program and Organizing Committees. As one of a series of biennial international symposia on combinatorial optimization, CO 2012 continues to attract participants from all over the world. It promises to include an excellent array of presentations about the advances of combinatorial(More)
  • Yingyao Hu, Yutaka Kayaba, Matt Shum, Dan Ackerberg, Peter Bossaerts, Colin Camerer +33 others
  • 2010
How do people learn? We assess, in a distribution-free manner, subjects' learning and choice rules in dynamic two-armed bandit (probabilistic reversal learning) experiments. To aid in identification and estimation, we use auxiliary measures of subjects' beliefs, in the form of their eye-movements during the experiment. Our estimated choice probabilities and(More)
Description of project: The following is an extract from the OPRRA user guide. The proposed project is likely to focus on the further studies mentioned in bold towards the end. 1. Aim. To assist pharmaceutical companies in taking decisions on rates of resource allocation during pre‐clinical pharmaceutical research which improve profitability. OPRRA should(More)
  • John R Hauser, Glen L Urban, Guilherme Liberali, Michael Braun, Andrew Gelman, John Gittins +1 other
  • 2009
W ebsite morphing draws on the Expected Gittins' solution to a partially observable Markov process, on the rapid consumer-segment updating with Bayesian methods, and on matching a website's look and feel to a visitor's cognitive style. In each area there are exciting research opportunities including optimality in the presence of switching costs (within a(More)