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We have determined the phosphorylation pattern of circulating insulin-like growth factor-binding protein-1 (IGFBP-1) in normal subjects and assessed how this changes in pregnancy. Two RIAs employing different monoclonal antibodies (MAbs 6303 or 6305) were used to measure IGFBP-1. In normal subjects, RIA 6303 measured 11-fold higher levels than RIA 6305(More)
O Op pt ti im ma al l a as ss se es ss sm me en nt t a an nd d m ma an na ag ge em me en nt t o of f c ch hr ro on ni ic c o ob bs st tr ru uc ct ti iv ve e p pu ul lm mo on na ar ry y d di is se ea as se e (Foreword Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. In the European Union, COPD and asthma, together(More)
Takens' theorem demonstrates that in the absence of noise a multidimensional state space can be reconstructed from a scalar time series. This theorem gives little guidance, however, about practical considerations for reconstructing a good state space. We extend Takens' treatment, applying statistical methods to incorporate the effects of observational noise(More)
The vast majority of randomized experiments in economics rely on a single baseline and single follow-up survey. If multiple follow-ups are conducted, the reason is typically to examine the trajectory of impact effects, so that in effect only one follow-up round is being used to estimate each treatment effect of interest. While such a design is suitable for(More)
Lower branch coherent states in plane Couette flow have an asymptotic structure that consists of O(1) streaks, O(R(-1)) streamwise rolls and a weak sinusoidal wave that develops a critical layer, for large Reynolds number R. Higher harmonics become negligible. These unstable lower branch states appear to have a single unstable eigenvalue at all Reynolds(More)
Pacific Island economies are some of the most remittance-dependent in the world. Proposals to lower the costs of sending money across borders are a core recommendation of recent international studies that aim to enhance the development impact of remittances. The potential increase in remittances that recipient countries can expect from such policies depends(More)
Type 2 diabetes is associated with biochemical evidence of low-grade inflammation, and experimental studies have suggested that both insulin and glucose affect inflammatory responses. To determine the effect of in vivo changes in glucose availability and plasma insulin concentrations in humans, we administered 20 U/kg Escherichia coli lipopolysaccharide(More)
BACKGROUND Despite exacerbations of chronic obstructive pulmonary disease (COPD) being both common and often fatal, accurate prognostication of patients hospitalised with an exacerbation is difficult. For exacerbations complicated by pneumonia, the CURB-65 prognostic tool is frequently used but its use in this population is suboptimal. METHODS Consecutive(More)