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Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin.
E-cadherin plays an essential role in cell polarity and cell-cell adhesion; however, the pathway for delivery of E-cadherin to the basolateral membrane of epithelial cells has not been fullyExpand
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Cell-matrix adhesion complexes: master control machinery of cell migration.
Cell-matrix adhesion complexes (CMACs) are foci of cellular attachment to the extracellular matrix (ECM). This attachment, mediated by integrins and adaptor proteins, provides both physical andExpand
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PtdIns(3,4,5)P3 is a regulator of myosin-X localization and filopodia formation
Phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] is a key regulator of cell signaling that acts by recruiting proteins to the cell membrane, such as at the leading edge during cellExpand
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E‐Cadherin Transport from the trans‐Golgi Network in Tubulovesicular Carriers is Selectively Regulated by Golgin‐97
E‐cadherin is a cell–cell adhesion protein that is trafficked and delivered to the basolateral cell surface. Membrane‐bound carriers for the post‐Golgi exocytosis of E‐cadherin have not beenExpand
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A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo
The transmembrane precursor of tumor necrosis factor-α (TNF) exits the trans-Golgi network (TGN) in tubular carriers for subsequent trafficking and delivery to the cell surface; however, theExpand
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Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions
Integrins are the core constituents of cell–matrix adhesion complexes such as focal adhesions (FAs) and play key roles in physiology and disease. Integrins fluctuate between active and inactiveExpand
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Single fluorescent protein-based Ca2+ sensors with increased dynamic range
BackgroundGenetically encoded sensors developed on the basis of green fluorescent protein (GFP)-like proteins are becoming more and more popular instruments for monitoring cellular analytes andExpand
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A plastic relationship between vinculin-mediated tension and adhesion complex area defines adhesion size and lifetime
Cell-matrix adhesions are central mediators of mechanotransduction, yet the interplay between force and adhesion regulation remains unclear. Here we use live cell imaging to map time-dependentExpand
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Technical Advance: Live‐imaging analysis of human dendritic cell migrating behavior under the influence of immune‐stimulating reagents in an organotypic model of lung
This manuscript describes technical advances allowing manipulation and quantitative analyses of human DC migratory behavior in lung epithelial tissue. DCs are hematopoietic cells essential for theExpand
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Domains of the TGN: Coats, Tethers and G Proteins
The trans‐Golgi network is the major sorting compartment of the secretory pathway for protein, lipid and membrane traffic. There is a constant flow of membrane and cargo to and from this compartment.Expand
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