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We describe the Harwell-Boeing sparse matrix collection, a set of standard test matrices for sparse matrix problems. Our test set comprises problems in linear systems, least squares, and eigenvalue calculations from a wide variety of scientific and engineering disciplines. The problems range from small matrices, used as counter-examples to hypotheses in(More)
An \industrial strength" algorithm for solving sparse symmetric generalized eigen-problems is described. The algorithm has its foundations in known techniques in solving sparse symmetric eigenproblems, notably the spectral transformation of Ericsson and Ruhe and the block Lanczos algorithm. However, the combination of these two techniques is not trivial;(More)
The critical bottlenecks in the implementation of the conjugate gradient algorithm on distributed memory computers are the communication requirements of the sparse matrix-vector multiply and of the vector recurrences. We describe the data distribution and communication patterns of jive general implementations, whose realizations demonstrate that the cost of(More)
Stress tolerance of Saccharomyces cerevisiae was examined after exposure to heat and salt shock in the presence or absence of the protein synthesis inhibitor cycloheximide. Cells heat-shocked (37 degrees C for 45 min) in the absence of cycloheximide demonstrated increased tolerance of heat, freezing and salt stress. For cells heat-shocked in the presence of(More)
BACKGROUND Glucocorticoid replacement is essential in patients with primary and secondary adrenal insufficiency, but many patients remain on higher than recommended dose regimens. There is no uniformly accepted method to monitor the dose in individual patients. We have compared cortisol concentrations in plasma, saliva and urine achieved following(More)
Phosphorothioate oligodeoxynucleotides containing the C-5 propyne analogs of uridine and cytidine bind RNA with high affinity and are potent antisense inhibitors of gene expression. In a cellular assay, gene-specific antisense inhibition occurred at nanomolar concentrations of oligonucleotide, was dose-dependent and exquisitely sensitive to sequence(More)
Four monoclonal antibodies to human sex hormone-binding globulin were raised and characterized. Three of the four antibodies recognised different antigenic determinants on SHBG. Two of the distinct antibodies were useful for Western blotting and recognized a major 48 kDa band in human plasma as well as a 46 kDa minor component. Carbohydrate residues do not(More)