John G. Attwood

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DNA methylation is the most stable type of epigenetic modification modulating the transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report high-resolution methylation profiles of human chromosomes 6, 20 and 22, providing a resource of about 1.9 million CpG methylation values derived from 12 different tissues. Analysis of(More)
The human genome sequence will provide a reference for measuring DNA sequence variation in human populations. Sequence variants are responsible for the genetic component of individuality, including complex characteristics such as disease susceptibility and drug response. Most sequence variants are single nucleotide polymorphisms (SNPs), where two alternate(More)
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human(More)
The alanine dosimetry system is now preferred by all primary and secondary calibration laboratories for their highdose ionizing radiation calibration services. Alanine dosimeters in the form of cylindrical pellets have been available in commercial quantities for several years. Despite their high quality, the physical dimensions of the dosimeter were not(More)
Florian Eckhardt1, Joern Lewin1, Rene Cortese1, Vardhman K Rakyan2, John Attwood2, Matthias Burger1, John Burton2, Tony V Cox2, Rob Davies2, Thomas A Down2, Carolina Haefliger1, Roger Horton2, Kevin Howe2, David K Jackson2, Jan Kunde1,3, Christoph Koenig1, Jennifer Liddle2, David Niblett2, Thomas Otto1, Roger Pettett2, Stefanie Seemann1, Christian(More)
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