John Freiling

Learn More
Chronic intermittent access to alcohol leads to the escalation of alcohol intake, similar to binge drinking in humans. Converging lines of evidence suggest that impairment of medial prefrontal cortex (mPFC) cognitive function and overactivation of the central nucleus of the amygdala (CeA) are key factors that lead to excessive drinking in dependence.(More)
Dopaminergic neurons in the ventral tegmental area (VTA) are well known for mediating the positive reinforcing effects of drugs of abuse. Here we identify in rodents and humans a population of VTA dopaminergic neurons expressing corticotropin-releasing factor (CRF). We provide further evidence in rodents that chronic nicotine exposure upregulates Crh mRNA(More)
Taryn E. Grieder1, Melissa A. Herman2, Candice Contet2, Laura A. Tan4, Hector VargasPerez1, Ami Cohen2, Michal Chwalek1, Geith Maal-Bared1, John Freiling2, Joel E Schlosburg2, Laura Clarke1, Elena Crawford2, Pascale Koebel5, Vez Canonigo3, Pietro Sanna3, Andrew Tapper6, Marisa Roberto2, Brigitte L. Kieffer5,7, Paul E. Sawchenko4, George F. Koob8, Derek van(More)
  • 1