John Frediani

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Design teams today are challenged with meeting time-to-market and cost constraints while product life cycles decrease and product complexity and functionality increases. Field Programmable Gate Arrays (FPGAs) and Complex Programmable Logic Devices (CPLDs) help meet these challenges by combining the short design cycle of PLDs with the application flexibility(More)
Oligodeoxynucleotide N3'-->P5' phosphoramidates are promising candidates for antisense therapeutics, as well as for diagnostic applications. We recently reported a new method for the synthesis of these oligonucleotide analogs which makes use of a phosphoramidite amine-exchange reaction in the key coupling step. We report herein an improved set of monomers(More)
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