Multiple asters (MAST)/Orbit is a member of a new family of nonmotor microtubule-associated proteins that has been previously shown to be required for the organization of the mitotic spindle. Here we provide evidence that MAST/Orbit is required for functional kinetochore attachment, chromosome congression, and the maintenance of spindle bipolarity. In vivo… (More)
The attachment zones of the meniscal horns of 7 dissecting room cadavers were examined by routine histology. All the knees were devoid of gross pathological change and no discoid menisci were included. Significant differences are reported in the thickness of the zones of uncalcified fibrocartilage and cortical calcified tissue (calcified fibrocartilage and… (More)
Recent studies that consider how vision is used in everyday life have led to a new perspective in visual science, in which more emphasis is placed on the active role of the viewer.
AIMS/HYPOTHESIS Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP) processing, modulates in vivo glucose disposal and insulin sensitivity in mice. Insulin-independent pathways… (More)
Individuals with Type 1 diabetes (T1D) are often exposed to recurrent episodes of hypoglycaemia. This reduces hormonal and behavioural responses that normally counteract low glucose in order to maintain glucose homeostasis, with altered responsiveness of glucose sensing hypothalamic neurons implicated. Although the molecular mechanisms are unknown,… (More)
Glucose hypometabolism and impaired mitochondrial function in neurons have been suggested to play early and perhaps causative roles in Alzheimer's disease (AD) pathogenesis. Activity of the aspartic acid protease, beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), responsible for beta amyloid peptide generation, has recently been… (More)
The authors report on a project in which a new experiential form of professional learning combined ethical thinking processes with a collaborative meeting technology known as the Zing team learning system (ZTLS). A new software program called Working Wisely was built by the completion of the project. The ZTLS in combination with Working Wisely facilitates… (More)