John F.Y. Brookfield

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P elements are transposable elements found in P strain, but usually not in M strain, Drosophila melanogaster, and are responsible for the hybrid dysgenesis that occurs when male D. melanogaster of the P strain mate with females of the M strain (ref. 1 and references therein). Several P elements, which vary in length and genetic effects, have now been(More)
The human genome contains a set of minisatellites, each of which consists of tandem repeats of a DNA segment containing the 'core' sequence, a putative recombination signal in human DNA. Multiallelic variation in the number of tandem repeats occurs at many of these minisatellite loci. Hybridization probes consisting of tandem repeats of the core sequence(More)
The draft of the human genome project reveals an unexpected distribution of Alu interspersed repetitive sequences [1]. This has been interpreted as evidence that Alu sequences 'may benefit their human hosts' [1] and that they 'have a positive function' [2]. The implication is that the majority of Alu sequences increase the Darwinian fitness of their(More)
Advances in data analysis and smooth non-linear modelling techniques enable the construction of accurate short range predictions for high dimensional chaotic systems. The techniques are illustrated using sunspot data. The ability to construct short/medium range predictions for chaotic dynamics also enables such systems to be controlled and some applications(More)
Laboratory evolution in Escherichia coli has revealed that fitness typically increases in experimental populations. These changes are sometimes associated with changes in insertion sequence positions, some of which may themselves cause advantageous phenotypes. We have a novel and general method for identifying genes in Escherichia coli, whose knockout by(More)