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BACKGROUND RNA-protein interactions stabilize many viruses and also the nucleoprotein cores of enveloped animal viruses (e.g. retroviruses). The nucleoprotein particles are frequently pleomorphic andContinue Reading
  • George Rice, Liang Tang, +6 authors Mark Young
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2004 (First Publication: 1 May 2004)
  • Of the three domains of life (Eukarya, Bacteria, and Archaea), the least understood is Archaea and its associated viruses. Many Archaea are extremophiles, with species that are capable of growth atContinue Reading
  • Charlotte Helgstrand, William R. Wikoff, Robert L Duda, Roger W. Hendrix, John Edward Johnson, Lars Liljas
  • Chemistry, Medicine
  • Journal of molecular biology
  • 2003 (First Publication: 1 December 2003)
  • The HK97 bacteriophage capsid is a unique example of macromolecular catenanes: interlocked rings of covalently attached protein subunits. The chain mail organization of the subunits stabilizes aContinue Reading
  • Reza Khayat, Liang Tang, Eric T. Larson, C Martin Lawrence, Mark E. Young, John Edward Johnson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 27 December 2005)
  • Archaea and their viruses are poorly understood when compared with the Eukarya and Bacteria domains of life. We report here the crystal structure of the major capsid protein (MCP) of the SulfolobusContinue Reading
  • George G Zhanel, Mel Decorby, +13 authors Daryl J. Hoban
  • Medicine
  • Antimicrobial agents and chemotherapy
  • 2008 (First Publication: 1 April 2008)
  • Between 1 September 2005 and 30 June 2006, 19 medical centers collected 4,180 isolates recovered from clinical specimens from patients in intensive care units (ICUs) in Canada. The 4,180 isolatesContinue Reading