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Neonicotinoid insecticide toxicology: mechanisms of selective action.

• Motohiro Tomizawa, John E. Casida
• Annual review of pharmacology and toxicology
• 2005

The neonicotinoids, the newest major class of insecticides, have outstanding potency and systemic action for crop protection against piercing-sucking pests, and they are highly effective for flea… (More)

Selective toxicity of neonicotinoids attributable to specificity of insect and mammalian nicotinic receptors.

• Motohiro Tomizawa, John E. Casida
• Annual review of entomology
• 2003

Neonicotinoids, the most important new class of synthetic insecticides of the past three decades, are used to control sucking insects both on plants and on companion animals. Imidacloprid (the… (More)

Neuroactive insecticides: targets, selectivity, resistance, and secondary effects.

• John E. Casida, Kathleen A. Durkin
• Annual review of entomology
• 2013

Neuroactive insecticides are the principal means of protecting crops, people, livestock, and pets from pest insect attack and disease transmission. Currently, the four major nerve targets are… (More)

Fipronil insecticide: novel photochemical desulfinylation with retention of neurotoxicity.

• Dominik Hainzl, John E. Casida
• Proceedings of the National Academy of Sciences…
• 1996

Fipronil is an outstanding new insecticide for crop protection with good selectivity between insects and mammals. The insecticidal action involves blocking the lambda-aminobutyric acid-gated chloride… (More)

Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues.

• Yimin Li, Carol MacKintosh, John E. Casida
• Biochemical pharmacology
• 1993

The target site for cantharidin (CA) and its analogues was isolated recently from mouse liver and identified as protein phosphatase (PP2A) in the heterodimeric form known as PP2A2. The most toxic CA… (More)

Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets.

• John E. Casida, Gary B. Quistad
• Chemical research in toxicology
• 2004

Ca2+-activated ryanodine binding: mechanisms of sensitivity and intensity modulation by Mg2+, caffeine, and adenine nucleotides.

• Isaac N Pessah, R A Stambuk, John E. Casida
• Molecular pharmacology
• 1987

The Ca2+-ryanodine receptor complex is a functional unit at the terminal cisternae (TC) of the sarcoplasmic reticulum (SR) whose proteins comprise the Ca2+ release channels which may be involved in… (More)

Structural model for gamma-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site.

• Ligong Chen, Kathleen A. Durkin, John E. Casida
• Proceedings of the National Academy of Sciences…
• 2006

Several major insecticides, including alpha-endosulfan, lindane, and fipronil, and the botanical picrotoxinin are noncompetitive antagonists (NCAs) for the GABA receptor. We showed earlier that human… (More)

[35S]t-butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to gamma-aminobutyric acid-A and ion recognition sites.

• Richard Felt Squires, John E. Casida, Michael B. Richardson, Else Saederup
• Molecular pharmacology
• 1983

Mechanisms of selective action of pyrethroid insecticides.

• John E. Casida, David W. Gammon, A H Glickman, Lens Lawrence
• Annual review of pharmacology and toxicology
• 1983

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