Learn More
Seizure predisposition in Genetically Epilepsy-Prone Rats (GEPRs) is characterized by abnormal sensitivity to a number of seizure provoking stimuli. The GEPR model is composed of two independently derived colonies with each exhibiting a characteristic convulsive pattern. In response to a standardized sound stimulus, GEPR-3s exhibit moderate or clonic(More)
Norepinephrine (NE) concentrations were measured in 15 discrete areas of the central nervous system of two types of genetically epilepsy-prone rats (GEPRs) and in nonepileptic controls. Both moderate-seizure (GEPR-3) and severe-seizure (GEPR-9) animals had extensive abnormalities in brain NE concentration. Deficits of equal magnitude in GEPR-3s and GEPR-9s(More)
Two side effects which limit the use of cisplatin in cancer chemotherapy are severe nephrotoxicity and ototoxicity. The concurrent administration of sodium thiosulfate with cisplatin reportedly protects from cisplatin nephrotoxicity, however, protection from ototoxicity has not been documented. The purpose of this study was to examine the efficacy of using(More)
Utilizing the Golgi technique, the present study provides a structural analysis of primate marginal (lamina I) neurons in the lumbosacral spinal cord. Marginal neurons are classified on the basis of major structural differences in dendritic conformation, distribution, and specialization. Cell size and shape alone were not found to be reliable criteria.(More)
Although numerous studies have shown that cochlear impairment exists in audiogenic-seizure (AGS)-susceptible mice, there is only one report of cochlear potentials obtained from AGS-susceptible rats. To investigate the hypothesis that cochlear impairment also exists in AGS rats, cochlear microphonics (CM) and the primary afferent activity of the auditory(More)
SUMMARY We show how to simultaneously reduce a pair of symmetric matrices to tridiagonal form by congruence transformations. No assumptions are made on the nonsingularity or definiteness of the two matrices. The reduction follows a strategy similar to the one used for the tridiagonalization of a single symmetric matrix via Householder reflectors. Two(More)
Drugs that produce tinnitus can be subdivided into those which produce temporary or permanent hearing loss and those which apparently do not cause any hearing loss. The tinnitus occurring with drugs of the first group is probably secondary to the hearing loss. However, most of the drugs that produce tinnitus without an accompanying hearing loss probably do(More)
The organ of Corti of Genetically Epilepsy Prone Rats was examined anatomically and electrophysiologically using scanning electron microscopy (SEM) and electrophysiological recording of alternating current cochlear potentials (ACCP) and N1, a volume conductor recording of the primary auditory afferent action potentials. ACCPs for GEPRs with low intensity(More)
The concept that changes in the dynamic behaviour of a rotor could be used for general fault detection and monitoring is well established. Current methods rely on the response of the machine to unbalance excitation and are mainly based on pattern recognition approaches. However these methods are relatively insensitive and the crack must be large before it(More)
This paper considers the problem of identifying damping in multi degree of freedom (MDOF) systems incorporating a cubic stiffness nonlinearity. The identification is carried out using techniques based on the limit curves at resonance, obtained by the Describing Function (OF) method. A limit curve may be described as an envelope outside which the forced(More)