John E Maloney

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The relationship between lung liquid flow and fetal lung development has been studied at the cellular level using ultrastructural techniques. Continuous in utero tracheal ligation and drainage (over a period of 21-28 days) both result in malformations of the developing fetal lamb lung. Ligated lungs are larger, and drained lungs are smaller, than normal(More)
In the sheep, fetal lung development proceeds to a later stage of maturity than in smaller laboratory animals. Of the four stages in pulmonary development recognizable in this species - embryologic, pseudoglandular, canalicular, and aveolar - the latter three are described in the present study using histologic, morphometric, and ultrastructural techniques.(More)
The ultrastructure of the developing fetal lamb myocardium was studied in a series of animals spanning 29 days of gestation to term, and compared with newborn and adult animals. All major ultrastructural features which characterise the adult myocyte were found in early fetal life, although with considerably different degrees of development of specific(More)
Baroreceptor reflexes can be demonstrated during fetal life, but whether baroreceptors normally regulate fetal arterial pressure is unknown. This problem was addressed directly by measuring arterial pressure and analyzing its variation in eight unanesthetized fetal lambs throughout the last third of gestation, and comparing these data with similar(More)
The immediate transient baroreceptor sensitivity was measured in 9 conscious fetal and 7 conscious newborn lambs for periods of at least 35 days following bolus injections of phenylephrine (20-50 mug/kg). Mean sensitivities were unchanged throughout gestation from 105 days at 6.7 +/- 0.4 msec/cm H2O (n = 45) and were insignificantly different from those in(More)